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Comment
. 2023 May 2;35(5):734-736.
doi: 10.1016/j.cmet.2023.04.008.

Energy saver: Monocytes hibernate in bone marrow upon fasting

Jan Tuckermann  1 , Pamela Fischer-Posovszky  2
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Free article
Comment

Energy saver: Monocytes hibernate in bone marrow upon fasting

Jan Tuckermann et al. Cell Metab. .
Free article

Abstract

Immune functions are influenced by the nutritional state. In a recent publication in Immunity, Janssen et al. unveil that a fasting-induced glucocorticoid release makes monocytes move from blood into the bone marrow. Upon refeeding, these chronologically older monocytes are again released and exert detrimental effects during bacterial infection.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Monocytes re-enter the bone marrow during fasting and alter the host response to infection.
    Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D'Souza D, McAlpine CS, Halle L, Poller WC, Chan CT, He S, Mindur JE, Kiss MG, Singh S, Anzai A, Iwamoto Y, Kohler RH, Chetal K, Sadreyev RI, Weissleder R, Kim-Schulze S, Merad M, Nahrendorf M, Swirski FK. Janssen H, et al. Immunity. 2023 Apr 11;56(4):783-796.e7. doi: 10.1016/j.immuni.2023.01.024. Epub 2023 Feb 23. Immunity. 2023. PMID: 36827982 Free PMC article.

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