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. 2023;16(4):292-299.
doi: 10.2174/1874471016666230502140224.

Determination of the Re-188 Calibration Number for the Capintec CRC- 25PET Dose Calibrator

Mitchell Ashley Klenner  1   2 , Aron Poole  1   2
Affiliations
Free article

Determination of the Re-188 Calibration Number for the Capintec CRC- 25PET Dose Calibrator

Mitchell Ashley Klenner et al. Curr Radiopharm. 2023.
Free article

Abstract

Background: During the development of novel Re-188 radiopharmaceuticals, it was discovered that no calibration settings were published to calibrate Re-188 on the Capintec CRC-25PET dose calibrator.

Methods: Sodium [188Re]perrhenate was eluted from an OncoBeta 188W/188Re generator to measure activity on a Capintec CRC-25R dose calibrator using established dose calibrator settings provided by the manufacturer. The eluent was then used to tune the calibra on settings on a Capintec CRC-25PET dose calibrator, accounting for geometry. Radionuclidic purity of the [188Re]perrhenate source was verified via gamma spectroscopy.

Results: The calibrator number for Re-188 was determined to be 469 x 10 for the Capintec CRC-25PET dose calibrator, which differed from the manufacturer provided calibra on number of 496 x 10 for the Capintec CRC-25R dose calibra on model. W-188 breakthrough was characterised as < 0.01%.

Conclusion: This previously unreported calibration number can be used to determine the activity of Re- 188 labelled radiopharmaceuticals using the Capintec CRC-25PET dose calibrator model.

Keywords: Rhenium-188; [188Re]perrhenate; calibration numbers; dose calibrators; radiopharmaceuticals; theranostics.

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