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Review
. 2023 Apr 27:16:1135-1144.
doi: 10.2147/CCID.S401447. eCollection 2023.

Hematoporphyrin Monomethyl Ether Photodynamic Therapy of Port Wine Stain: Narrative Review

Ping Diao  1 , Chenglong Han  1 , Xiaoxue Li  1 , Yi Yang  1 , Xian Jiang  1
Affiliations
Review

Hematoporphyrin Monomethyl Ether Photodynamic Therapy of Port Wine Stain: Narrative Review

Ping Diao et al. Clin Cosmet Investig Dermatol. .

Abstract

Port wine stain (PWS) is a congenital and progressive capillary malformation characterized by structural abnormalities of intradermal capillaries and postcapillary venules. The visible manifestation is often considered a disfigurement and the accompanying social stigma often causes serious emotional and physical impact. Hematoporphyrin monomethyl ether (HMME) is a newly authorized photosensitizer for treating PWS in China. Hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) has successfully treated thousands of Chinese patients with PWS since 2017, and HMME-PDT may be one of the most promising strategies for the treatment of PWS. However, there are few reviews published about the clinical use of HMME-PDT. So in this article, we want to briefly review the mechanism, efficacy evaluation, effectiveness and influencing factors, and the common postoperative reactions and treatment suggestions of HMME-PDT in the treatment of PWS.

Keywords: HMME; PDT; photodynamic therapy; photosensitizer; port wine stain.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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