Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 May 4;13(5):1046-1048.
doi: 10.1158/2159-8290.CD-23-0200.

p53 Oligomerization Domain Mutants: A New Class of Mutants That Retain "License to Kill"

David Stieg  1 , Kaitlyn Casey  1   2 , Maureen E Murphy  1
Affiliations
Editorial

p53 Oligomerization Domain Mutants: A New Class of Mutants That Retain "License to Kill"

David Stieg et al. Cancer Discov. .

Abstract

In this issue of Cancer Discovery, companion articles from the Prives and Lozano groups describe functional analyses of a common dimeric mutant of p53 found in Li-Fraumeni disease and sporadic cancer: A347D (AD). The authors show that the AD mutant is completely defective for canonical p53 transcriptional function, but interestingly retains some tumor suppressor function, which they show is manifested as "neomorphic" activities in transcription and the control of mitochondrial metabolism. See related article by Gencel-Augusto et al., p. 1230 (7). See related article by Choe et al., p. 1250 (6).

PubMed Disclaimer

Comment on

Substances

LinkOut - more resources