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. 2023 Aug;81(2):330-339.
doi: 10.1007/s12020-023-03375-x. Epub 2023 May 4.

Prolactin and spermatogenesis: new lights on the interplay between prolactin and sperm parameters

Giorgia Spaggiari  1   2 , Francesco Costantino  1   3 , Antonio R M Granata  1   2 , Simonetta Tagliavini  4 , Giulia Canu  4 , Manuela Varani  4 , Maria Cristina De Santis  4 , Laura Roli  4 , Tommaso Trenti  4 , Manuela Simoni  1   3 , Daniele Santi  5   6   7
Affiliations

Prolactin and spermatogenesis: new lights on the interplay between prolactin and sperm parameters

Giorgia Spaggiari et al. Endocrine. 2023 Aug.

Abstract

Purpose: To clarify the relationship between one the most gender-specific hormone, i.e. prolactin (PRL), and semen parameters in men.

Methods: A retrospective, observational, cohort, real-world study was carried out, enrolling all men performing a semen analysis and PRL examination from 2010 to 2022. For each patient, the first semen analys was extracted, associated to PRL, total testosterone (TT), follicle stimulating hormone (FSH) and luteinizing hormone (LH). Hyperprolactinaemia (>35 ng/mL) was excluded.

Results: 1211 subjects were included. PRL serum levels were lower in normozoospermia compared to azoospermia (p = 0.002) and altered semen parameters (p = 0.048) groups. TT serum levels were not different among groups (p = 0.122). Excluding azoospermic men, PRL serum levels were lower in normozoospermic patients, when compared to other groups of semen alterations. An inverse correlation was detected between PRL and sperm concentration. Considering normozospermic subjects, PRL was directly related to both non-progressive sperm motility (p = 0.014) and normal sperm morphology (p = 0.040). Subdiving the cohort in quartiles according to PRL distribution, the highest motilities were observed in the second PRL quartile (8.30-11.10 ng/mL) and asthenozoospermia was significantly predicted by FSH (p < 0.001) and second PRL quartile (p = 0.045).

Conclusion: The PRL-spermatogenesis connection seems to be mild, although low-normal PRL levels are associated with the best spermatogenetic profile. PRL serum levels could mirror the immunoregulatory status within the testis, suggesting that there is a sort of 'PRL optimal window' reflecting an efficent spermatogenesis. Alternatively, men with good semen parameters might have a higher central dopaminergic tone resulting in low PRL levels.

Keywords: FSH; Prolactin; Semen analysis; Sperm concentration; Sperm motility.

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References

    1. I. Dresel, The effect of prolactin on the estrus cycle of nonparous mice. Science (New York, NY) 82(2121), 173 (1935). https://doi.org/10.1126/science.82.2121.173 - DOI
    1. G. Rastrelli, G. Corona, M. Maggi, The role of prolactin in andrology: what is new. Rev. Endocr. Metab. Disord. 16(3), 233–248 (2015). https://doi.org/10.1007/s11154-015-9322-3 - DOI - PubMed
    1. V. Bernard, J. Young, N. Binart, Prolactin - a pleiotropic factor in health and disease. Nat. Rev. Endocr. 15(6), 356–365 (2019). https://doi.org/10.1038/s41574-019-0194-6 - DOI
    1. I.C. Chikanza, Prolactin and neuroimmunomodulation: in vitro and in vivo observations. Annals N.Y. Acad. Sci. 876, 119–130 (1999). https://doi.org/10.1111/j.1749-6632.1999.tb07629.x - DOI
    1. Hypoprolactinaemia (1987). Lancet 1 (8546):1356–1357

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