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. 2023 Jun 1;141(6):1049-1051.
doi: 10.1097/AOG.0000000000005157. Epub 2023 May 3.

Rhabdomyolysis After Intravenous Iron Sucrose Infusion During Pregnancy

Christina Ge  1 , Jessica Reyes, Ruth Anne Queenan, Robert B Gherman
Affiliations

Rhabdomyolysis After Intravenous Iron Sucrose Infusion During Pregnancy

Christina Ge et al. Obstet Gynecol. .

Abstract

Background: Iron infusions have become increasingly common in the treatment of iron-deficiency anemia during pregnancy. Although iron infusions are generally well tolerated, adverse reactions have been reported.

Case: A pregnant patient was diagnosed with rhabdomyolysis after receiving a second dose of intravenous (IV) iron sucrose at 32 6/7 weeks of gestation. On admission to the hospital, creatine kinase was 2,437 units/L, sodium was 132 mEq/L, and potassium was 2.1 mEq/L. Intravenous fluids and electrolyte repletion were administered, with improvement of symptoms within 48 hours. Creatinine kinase normalized 1 week after hospital discharge.

Conclusion: Rhabdomyolysis can be associated with IV iron infusion during pregnancy.

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Conflict of interest statement

Financial Disclosure Robert Gherman, MD, serves as a strategic advisor to Fetal Ease, Ltd. He has served as an expert witness in medical/legal cases. The other authors did not report any potential conflicts of interest.

Comment in

References

    1. Bencaiova G, Burkhardt T, Breymann C. Anemia: prevalence and risk factors in pregnancy. Eur J Intern Med 2012;23:529–33. doi: 10.1016/j.ejim.2012.04.008 - DOI
    1. Haider BA, Olofin I, Wang M, Spiegelman D, Ezzati M, Fawzi WW. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ 2013;346:f3443. doi: 10.1136/bmj.f3443 - DOI
    1. Smith C, Teng F, Branch E, Chu S, Joseph KS. Maternal and perinatal morbidity and mortality associated with anemia in pregnancy. Obstet Gynecol 2019;134:1234–44. doi: 10.1097/aog.0000000000003557 - DOI
    1. Quezada-Pinedo HG, Cassel F, Duijts L, Muckenthaler MU, Gassmann M, Jaddoe VWV, et al. Maternal iron status in pregnancy and child health outcomes after birth: a systematic review and meta-analysis. Nutrients 2021;13:2221. doi: 10.3390/nu13072221 - DOI
    1. Breymann C, Honegger C, Holzgreve W, Surbek D. Diagnosis and treatment of iron-deficiency anaemia during pregnancy and postpartum. Arch Gynecol Obstet 2010;282:577–80. doi: 10.1007/s00404-010-1532-z - DOI

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