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Review
. 2023 Jul:150:105210.
doi: 10.1016/j.neubiorev.2023.105210. Epub 2023 May 2.

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis

Anna Vannucci  1 , Andrea Fields  2 , Eleanor Hansen  3 , Ariel Katz  3 , John Kerwin  3 , Ayumi Tachida  3 , Nathan Martin  3 , Nim Tottenham  4
Affiliations
Review

Interpersonal early adversity demonstrates dissimilarity from early socioeconomic disadvantage in the course of human brain development: A meta-analysis

Anna Vannucci et al. Neurosci Biobehav Rev. 2023 Jul.

Abstract

It has been established that early-life adversity impacts brain development, but the role of development itself has largely been ignored. We take a developmentally-sensitive approach to examine the neurodevelopmental sequelae of early adversity in a preregistered meta-analysis of 27,234 youth (birth to 18-years-old), providing the largest group of adversity-exposed youth to date. Findings demonstrate that early-life adversity does not have an ontogenetically uniform impact on brain volumes, but instead exhibits age-, experience-, and region-specific associations. Relative to non-exposed comparisons, interpersonal early adversity (e.g., family-based maltreatment) was associated with initially larger volumes in frontolimbic regions until ∼10-years-old, after which these exposures were linked to increasingly smaller volumes. By contrast, socioeconomic disadvantage (e.g., poverty) was associated with smaller volumes in temporal-limbic regions in childhood, which were attenuated at older ages. These findings advance ongoing debates regarding why, when, and how early-life adversity shapes later neural outcomes.

Keywords: Adolescence; Adverse experiences; Brain structure; Childhood; Development; Early life stress; Maltreatment; Neurodevelopment; Poverty.

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Conflict of interest statement

Declarations of Competing Interest None.

Figures

Figure 1.
Figure 1.
PRISMA flow diagram for systematic review.
Figure 2.
Figure 2.. Age-dependent associations between early-life adversity and brain volume.
A. All age-dependent associations indicate that the magnitude of the association between early adversity exposure (vs. no exposure) and brain volume changes with age. pink = negative age-related change with interpersonal early adversity (vs. non-exposed comparison); green = positive age-related change with higher (vs. lower) early socioeconomic disadvantage; dark gray = no age-related associations with either type of early adversity exposure. B. Amygdala and hippocampus show different age-related associations for interpersonal early adversity exposure (vs. no exposure) and early socioeconomic disadvantage. The size of the points reflects the relative sample size. Other regions not shown here exhibit comparable patterns of age-related change for interpersonal early adversity (ventral anterior cingulate cortex [vACC], ventrolateral prefrontal cortex [vlPFC], ventromedial prefrontal cortex [vmPFC]; see Supplementary Information, Figure S24) and early socioeconomic disadvantage (parahippocampus; inferior, middle, and superior temporal gyri; see Supplementary Information, Figure S25). C. Interpersonal early adversity preferentially shapes frontolimbic circuitry, with age-related changes supporting adversity-induced acceleration models. That is, interpersonal early adversity may contribute to early adversity-induced acceleration in childhood with a long-term tradeoff of later allostatic overload and attenuated neural plasticity. Early socioeconomic disadvantage preferentially shapes cortical-limbic structures.
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References

    1. Amso D, Lynn A, 2017. Distinctive mechanisms of adversity and socioeconomic inequality in child development: a review and recommendations for evidence-based policy. Policy Insights Behav. Brain Sci 4, 139–146. 10.1177/2372732217721933 - DOI - PMC - PubMed
    1. Baldwin JR, Sallis HM, Schoeler T, Taylor MJ, Kwong AS, Tielbeek JJ, Barkhuizen W, Warrier V, Howe LD, Danese A, McCrory E, 2023. A genetically informed Registered Report on adverse childhood experiences and mental health. Nat. Hum. Behav 7(2), 269–290. 10.1038/s41562-022-01482-9 - DOI - PMC - PubMed
    1. Barch DM, Donohue MR, Elsayed NM, Gilbert K, Harms MP, Hennefield L, Herzberg M, Kandala S, Karcher NR, Jackson JJ, Luking KR, Rappaport BI, Sanders A, Taylor R, Tillman R, Vogel AC, Whalen D, Luby JL, 2022. Early childhood socioeconomic status and cognitive and adaptive outcomes at the transition to adulthood: the mediating role of gray matter development across 5 scan waves. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 7(1), 10.1016/j.bpsc.2021.07.002 - DOI - PMC - PubMed
    1. Barch DM, Shirtcliff EA, Elsayed NM, Whalen D, Gilbert K, Vogel AC, Tillman R, Luby JL, 2020. Testosterone and hippocampal trajectories mediate the relationship of poverty to emotion dysregulation and depression. Proc. Natl. Acad. Sci 117, 22015–22023. 10.1073/pnas.2004363117 - DOI - PMC - PubMed
    1. Bath KG, Schilit A, Lee FS, 2013. Stress effects on BDNF expression: Effects of age, sex, and form of stress. Neuroscience, 239, 149–156. 10.1016/j.neuroscience.2013.01.074 - DOI - PubMed