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Comment
. 2023 Sep;33(9):657-658.
doi: 10.1038/s41422-023-00814-2.

Sensing unsaturated fatty acids: insights from GPR120 signaling

Shicheng Zhang  1 , Bryan L Roth  2
Affiliations
Comment

Sensing unsaturated fatty acids: insights from GPR120 signaling

Shicheng Zhang et al. Cell Res. 2023 Sep.
No abstract available

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Figures

Fig. 1
Fig. 1. Signaling bias of GPR120 agonists and recognition of unsaturated bonds in FAs by the aromatic array in GPR120.
GPR120 agonists (TUG891, EPA, 9-HSA, LA, and OA) are shown in both stick and sphere models and colored in gray. GPR120 (PDB: 8G59), Gq heterotrimer (PDB: 8G59), Gi/o heterotrimer (PDB: 8ID8), and Gs heterotrimer (PDB: 7XTC) are shown in both ribbon and surface models. GPR120, Gq, Gi/o, Gs, Gβ and Gγ are colored in green, yellow, sky blue, orange, cyan and magenta, respectively. Signaling pathways induced by TUG891, EPA, and other FAs (9-HSA, LA, and OA) are indicated by blue, red, and gray arrows, respectively. As an example, the interactions between EPA and GPR120 in the orthosteric binding pocket are shown in the inset panel. EPA and nine aromatic residues involved in the recognition of the unsaturated bonds in FAs are shown in the ball and stick model, and colored in gray and green, respectively. Specifically, the double bonds in EPA are colored in deep purple. All the oxygen and nitrogen atoms are colored in red and blue, respectively.
See this image and copyright information in PMC

Comment on

  • Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
    Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP. Mao C, et al. Science. 2023 Apr 7;380(6640):eadd6220. doi: 10.1126/science.add6220. Epub 2023 Apr 7. Science. 2023. PMID: 36862765

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