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Comment
. 2023 May;8(5):762-763.
doi: 10.1038/s41564-023-01373-3.

Autophagy is part of the answer to tuberculosis

Vojo Deretic  1   2 , Fulong Wang  3   4
Affiliations
Comment

Autophagy is part of the answer to tuberculosis

Vojo Deretic et al. Nat Microbiol. 2023 May.
No abstract available

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Figures

Figure:
Figure:
Canonical and non-canonical ATG-dependent processes contribute to control of M. tuberculosis.
See this image and copyright information in PMC

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References

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    1. Watson RO, Manzanillo PS & Cox JS Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway. Cell 150, 803–815, doi:10.1016/j.cell.2012.06.040 (2012). - DOI - PMC - PubMed
    1. Castillo EF et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proceedings of the National Academy of Sciences of the United States of America 109, E3168–3176, doi:10.1073/pnas.1210500109 (2012). - DOI - PMC - PubMed
    1. Kimmey JM et al. Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection. Nature 528, 565–569, doi:10.1038/nature16451 (2015). - DOI - PMC - PubMed
    1. Golovkine G. Enhanced depletion of ATG7 and ATG16L1 in myeloid cells reveals a key role for autophagy in resistance to Mycobacterium tuberculosis infection. Nature Microbiology In press (2023).