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Review
. 2023 Apr 28:12:9.
doi: 10.12703/r/12-9. eCollection 2023.

From Translation to Treatment

Xuemin Wang  1 , Christopher G Proud  1
Affiliations
Review

From Translation to Treatment

Xuemin Wang et al. Fac Rev. .

Abstract

Protein synthesis (mRNA translation) plays a crucial role in cell function by shaping the proteome -making all the proteins each cell requires at the right time and in the right quantities and places. Proteins carry out almost every job in the cell. Protein synthesis is also a major component of the cellular economy, using large amounts of metabolic energy and resources, especially amino acids. Accordingly, it is tightly regulated through diverse mechanisms which respond, for example, to nutrients, growth factors, hormones, neurotransmitters and stressful situations.

Keywords: MNK; VWM; eIF2B; eIF4E; mTORC1.

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Conflict of interest statement

CGP consults for AUM Biosciences in the area of MNK inhibitors and possible therapeutic agents. XW has no competing interests to declare.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Control of translation initiation.
This figure depicts, in a greatly simplified way, the major points about the initiation of mRNA translation and its regulation which are discussed in the text. (A) overview of the major steps; TC = ternary complex; note that it is the eIF4E component of eIF4F that interacts with the 5’-cap (see also panel B). (B) mTORC1 regulates the formation of eIF4F complexes via phosphorylation of 4E-BPs, while MNKs phosphorylate eIF4E. (C) eIF2 forms ternary complexes, which require it to be bound to GTP. Regeneration of eIF2•GTP is mediated by eIF2B, and this process is inhibited by phosphorylated eIF2.
See this image and copyright information in PMC

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