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. 2023 Apr 18:13:1169133.
doi: 10.3389/fonc.2023.1169133. eCollection 2023.

Surgical treatment for recurrent cholangiocarcinoma: a single-center series

Laura Fernández  1 , Mikel Gastaca  2   3 , Eva Alonso  4 , Mikel Prieto  2   3 , Patricia Ruiz  2 , Alberto Ventoso  2 , Ibone Palomares  2 , Arkaitz Perfecto  2 , Andrés Valdivieso  2   3
Affiliations

Surgical treatment for recurrent cholangiocarcinoma: a single-center series

Laura Fernández et al. Front Oncol. .

Abstract

Purpose: The present study aims to assess the results obtained after surgical treatment of cholangiocarcinoma (CC) recurrences.

Methods: We carried out a single-center retrospective study, including all patients with recurrence of CC. The primary outcome was patient survival after surgical treatment compared with chemotherapy or best supportive care. A multivariate analysis of variables affecting mortality after CC recurrence was performed.

Results: Eighteen patients were indicated surgery to treat CC recurrence. Severe postoperative complication rate was 27.8% with a 30-day mortality rate of 16.7%. Median survival after surgery was 15 months (range 0-50) with 1- and 3-year patient survival rates of 55.6% and 16.6%, respectively. Patient survival after surgery or CHT alone, was significantly better than receiving supportive care (p< 0.001). We found no significant difference in survival when comparing CHT alone and surgical treatment (p=0.113). Time to recurrence of <1 year, adjuvant CHT after resection of the primary tumor and undergoing surgery or CHT alone versus best supportive care were independent factors affecting mortality after CC recurrence in the multivariate analysis.

Conclusion: Surgery or CHT alone improved patient survival after CC recurrence compared to best supportive care. Surgical treatment did not improve patient survival compared to CHT alone.

Keywords: chemotherapy; cholangiocarcinoma; outcomes; recurrence; surgical treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of patients with cholangiocarcinoma according to treatment of recurrence.
Figure 2
Figure 2
Survival of cholangiocarcinoma recurrence according to the treatment received. Surgery or systemic chemotherapy only vs best supportive therapy (p<0.001). Surgery vs systemic chemotherapy only (p=0.308).
Figure 3
Figure 3
Survival after cholangiocarcinoma recurrence: R0/R1 resection vs systemic chemotherapy only (p=0.113).
See this image and copyright information in PMC

References

    1. Nakeeb A, Pitt HA, Sohn TA, Coleman J, Abrams RA, Piantadosi S, et al. . Cholangiocarcinoma. a spectrum of intrahepatic, perihilar, and distal tumors. Ann Surg (1996) 224:463–73. doi: 10.1097/00000658-199610000-00005 - DOI - PMC - PubMed
    1. Kayahara M, Nagakawa T, Nakagawara H, Kitagawa H, Ohta T. Prognostic factors for gallbladder cancer in Japan. Ann Surg (2008) 248:807–14. doi: 10.1097/SLA.0b013e31818a1561 - DOI - PubMed
    1. Sano T, Shimada K, Sakamoto Y, Yamamoto J, Yamasaki S, Kosuge T, et al. . One hundred two consecutive hepatobiliary resections for perihilar cholangiocarcinoma with zero mortality. Ann Surg (2006) 244:240–7. doi: 10.1097/01.sla.0000217605.66519.38 - DOI - PMC - PubMed
    1. Endo I, Gonen M, Yopp AC, Dalal KM, Zhou Q, Klimstra D, et al. . Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection. Ann Surg (2008) 248:84–96. doi: 10.1097/SLA.0b013e318176c4d3 - DOI - PubMed
    1. Kobayashi A, Miwa S, Nakata T, Miyagawa S. Disease recurrence patterns after R0 resection of hilar cholangiocarcinoma. Br J Surg (2010) 97:56–64. doi: 10.1002/bjs.6788 - DOI - PubMed

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