Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 1;18(3):126-134.
doi: 10.1097/COH.0000000000000789. Epub 2023 Mar 20.

Long COVID in people living with HIV

Michael J Peluso  1 , Annukka A R Antar  2
Affiliations
Review

Long COVID in people living with HIV

Michael J Peluso et al. Curr Opin HIV AIDS. .

Abstract

Purpose of review: It is now recognized that SARS-CoV-2 infection can have a long-term impact on health. This review summarizes the current state of knowledge regarding Long COVID in people living with HIV (PLWH).

Recent findings: PLWH may be at elevated risk of experiencing Long COVID. Although the mechanisms contributing to Long COVID are incompletely understood, there are several demographic and clinical factors that might make PLWH vulnerable to developing Long COVID.

Summary: PLWH should be aware that new or worsening symptoms following SARS-CoV-2 infection might represent Long COVID. HIV providers should be aware of this clinical entity and be mindful that their patients recovering from SARS-CoV-2 infection may be at higher risk.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest. MJP reports consulting fees from Gilead Sciences and AstraZeneca.

Figures

Figure 1.
Figure 1.. Potential contributors to Long COVID in people living with HIV (PLWH).
PLWH may be at elevated risk for Long COVID and other post-acute sequelae following SARS-CoV-2 infection. While the risk factors for and mechanisms of such sequelae are incompletely understood, there are a variety of clinical, demographic, immunologic, and physiologic factors that could explain why PLWH might experience increased vulnerability to complications in the post-acute phase of SARS-CoV-2 infection. “?” indicates potential contributors with limited strength of evidence.
See this image and copyright information in PMC

References

    1. Callard F, Perego E: How and why patients made Long Covid. Soc Sci Med 2021, 268:113426. - PMC - PubMed
    1. Tenforde MW, Kim SS, Lindsell CJ, Billig Rose E, Shapiro NI, Files DC, Gibbs KW, Erickson HL, Steingrub JS, Smithline HA, et al.: Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020. MMWR Morb Mortal Wkly Rep 2020, 69:993–998. - PMC - PubMed
    1. NIH launches new initiative to study “Long COVID.” National Institutes of Health (NIH) 2021,
    1. The White House: Memorandum on addressing the Long-Term Effects of COVID-19. The White House 2022,
    1. Coronavirus: Coronavirus » Long COVID: the NHS plan for 2021/22. [date unknown],