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. 2023 Jul;42(7):907-912.
doi: 10.1007/s10096-023-04618-5. Epub 2023 May 5.

The interaction between liver cirrhosis, infection by Streptococcus bovis, and colon cancer

Juan Corredoira  1 , Enrique Miguez  2 , Lara María Mateo  3 , Ricardo Fernández-Rodríguez  4 , José Francisco García-Rodríguez  5 , Alexandre Pérez-González  6 , Ana Sanjurjo  7 , María Victoria Pulian  8 , Blanca Ayuso-García  9 ; In behalf all members of GESBOGA group
Collaborators, Affiliations

The interaction between liver cirrhosis, infection by Streptococcus bovis, and colon cancer

Juan Corredoira et al. Eur J Clin Microbiol Infect Dis. 2023 Jul.

Abstract

Whether cirrhotic patients with Streptococcus bovis bacteremia have an increased risk of colorectal neoplasm is uncertain. A multicentric retrospective cohort study was conducted investigating associations between S. bovis biotype and species, cirrhosis, and colorectal neoplasm. Out of 779 patients with S. bovis bacteremia, 69 (8.7%) had cirrhosis. No differences were found in the prevalence of colorectal neoplasm between cirrhotic and non-cirrhotic patients undergoing colonoscopy. Among cirrhotic patients, prevalence of colorectal neoplasms was higher in S. bovis biotype I (S. gallolyticus) bacteremia (80%) than in S. bovis biotype II (33.3%; p < 0.007). In conclusion, risk of colorectal neoplasm is high among cirrhotic patients with S. gallolyticus bacteremia.

Keywords: Bacteriemia; Colonoscopy; Colorectal neoplasm; Liver cirrhosis; Streptococcus bovis.

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