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. 2023:2667:87-98.
doi: 10.1007/978-1-0716-3199-7_6.

Mouse Model of Latent Cryptococcal Infection and Reactivation

Ko Sato  1   2 , Kazuyoshi Kawakami  3   4
Affiliations

Mouse Model of Latent Cryptococcal Infection and Reactivation

Ko Sato et al. Methods Mol Biol. 2023.

Abstract

AbstractCryptococcus neoformans is an opportunistic fungal pathogen that frequently causes fatal meningoencephalitis in patients with impaired immune responses. This fungus, an intracellularly growing microbe, evades host immunity, leading to a latent infection (latent C. neoformans infection: LCNI), and cryptococcal disease is developed by its reactivation when host immunity is suppressed. Elucidation of the pathophysiology of LCNI is difficult due to the lack of mouse models. Here we show the established methods for LCNI and reactivation.

Keywords: Cryptococcus neoformans; Latent infection; Mouse model; Reactivation.

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References

    1. Perfect JR, Casadevall A (2002) Cryptococcosis. Infect Dis Clin North Am 16:837–874, v–vi
    1. Lim TS, Murphy JW (1980) Transfer of immunity to cryptococcosis by T-enriched splenic lymphocytes from Cryptococcus neoformans-sensitized mice. Infect Immun 30:5–11 - DOI - PubMed - PMC
    1. Koguchi Y, Kawakami K (2002) Cryptococcal infection and Th1-Th2 cytokine balance. Int Rev Immunol 21:423–428 - DOI - PubMed
    1. Sato K, Kawakami K (2017) Recognition of Cryptococcus neoformans by pattern recognition receptors and its role in host defense to this infection. Med Mycol J 58:J83–J90 - DOI - PubMed
    1. Arora S, Olszewski MA, Tsang TM et al (2011) Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans. Infect Immun 79:1915–1926 - DOI - PubMed - PMC

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