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Comment
. 2023 May 4;83(9):1372-1374.
doi: 10.1016/j.molcel.2023.04.004.

Bilayer STING goes head to head to stay put

Kun Yang  1 , Nan Yan  2
Affiliations
Comment

Bilayer STING goes head to head to stay put

Kun Yang et al. Mol Cell. .

Abstract

In this issue, Liu et al.1 provide structural insights into how STING remains inactive. Apo-STING adopts a bilayer conformation exhibiting head-to-head and side-to-side interactions in its autoinhibitory state on the ER. The apo-STING oligomer differs from the activated STING oligomer in its biochemical stability, protein domain contact, and membrane curvature.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • The mechanism of STING autoinhibition and activation.
    Liu S, Yang B, Hou Y, Cui K, Yang X, Li X, Chen L, Liu S, Zhang Z, Jia Y, Xie Y, Xue Y, Li X, Yan B, Wu C, Deng W, Qi J, Lu D, Gao GF, Wang P, Shang G. Liu S, et al. Mol Cell. 2023 May 4;83(9):1502-1518.e10. doi: 10.1016/j.molcel.2023.03.029. Epub 2023 Apr 21. Mol Cell. 2023. PMID: 37086726

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