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Comment
. 2023 May 5;61(5):2300426.
doi: 10.1183/13993003.00426-2023. Print 2023 May.

Reply: Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis

CRyPTIC Consortium
Comment

Reply: Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis

CRyPTIC Consortium. Eur Respir J. .

Abstract

The recent publication by the @crypticproject proposing ECOFF/ECVs for research attracted two letters to the editor. Here is the response from the CRyPTIC Consortium to both. https://bit.ly/40vRLye

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Conflict of interest statement

Conflict of interest: For conflict of interest statements for members of the CRyPTIC Consortium, please see the original manuscript.

Comment on

References

    1. The CRyPTIC Consortium . Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis. Eur Respir J 2022; 60: 2200239. doi: 10.1183/13993003.00239-2022 - DOI - PMC - PubMed
    1. The CRyPTIC Consortium . A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics. PLoS Biol 2022; 20: e3001721. doi: 10.1371/journal.pbio.3001721 - DOI - PMC - PubMed
    1. Fowler PW, Gibertoni Cruz AL, Hoosdally SJ, et al. . Automated detection of bacterial growth on 96-well plates for high-throughput drug susceptibility testing of Mycobacterium tuberculosis. Microbiology (NY) 2018; 164: 1522–1530. doi: 10.1099/mic.0.000733 - DOI - PubMed
    1. Fowler PW, Wright C, Spiers H, et al. . A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates. Elife 2022; 11: e75046. doi: 10.7554/eLife.75046 - DOI - PMC - PubMed
    1. World Health Organization . Technical Report on Critical Concentrations for Drug Susceptibility Testing of Medicines Used in the Treatment of Drug-resistant Tuberculosis. Geneva, World Health Organization, 2018. Date last accessed: 9 March 2023. www.who.int/publications/i/item/WHO-CDS-TB-2018.5

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