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. 2023 Aug;82(8):1117-1120.
doi: 10.1136/ard-2023-223952. Epub 2023 May 5.

Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

Christina Bergmann  1   2 , Fabian Müller  2   3 , Jörg H W Distler  1   2   4   5 , Andrea-Hermina Györfi  4   5 , Simon Völkl  2   3 , Michael Aigner  2   3 , Sascha Kretschmann  2   3 , Hannah Reimann  2   3 , Thomas Harrer  1   2 , Nadine Bayerl  6 , Sebastian Boeltz  1   2 , Andreas Wirsching  1   2 , Jule Taubmann  1   2 , Wolf Rösler  2   3 , Bernd Spriewald  2   3 , Jochen Wacker  1   2 , Armin Atzinger  7 , Michael Uder  6 , Torsten Kuwert  7 , Andreas Mackensen  2   3 , Georg Schett  8   2
Affiliations

Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells

Christina Bergmann et al. Ann Rheum Dis. 2023 Aug.
No abstract available

Keywords: B-Lymphocytes; Systemic Sclerosis; Treatment.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Patient with severe diffuse systemic sclerosis treated with CD19-CAR T cells. (A) Dot plot showing expression of CD3 (y-axis) and CD19-CAR (x-axis) quantifying the circulating CD19-CAR T cells by FACS on days 3 and 9 after infusion. (B) Time course of absolute and relative numbers of circulating CD19-CAR T cells and CD19+ B cells; d0=01.080.2022. (C) Densitometric analysis of autoantibodies against RNAPIII, subunit RP11 at baseline (1 month prior to CAR T-cell infusion) and 3 months after CAR T-cell therapy. (D) PET showing resolution of fibroblast activation protein inhibitor (68Ga-FAPI-04) tracer accumulation in the heart at baseline and 3 months after CAR T-cell therapy. (E) Axial and coronal sections of T1-weighted contrast-enhanced MRI of the hands at baseline and 3 months after CAR T-cell therapy. (F) EUSTAR activity index, (G) mRSS and (H) lung function parameters at baseline and 3 months after CAR T-cell therapy. mRSS changes (G) were visualised using a modified version of the scheme described in Khanna D, Furst de, et al. J scleroderma relat Disord.2017 Jan-Apr;2 (1):11–18.doi:10.5301/jsrd.5000231. CAR, chimeric antigen receptor; CRP, C reactive protein; DLCO, diffusing capacity or transfer factor of the lung for carbon monoxide; EF, ejection fraction; FACS, fluorescence-activated cell scanner; KCO, carbon monoxide transfer coefficient; mRSS, modified Rodnan Skin Score; PASP, pulmonary artery systolic pressure; PET, positron emission tomography; PFT, pulmonary function tests; RA, right atrium; SUV, standard uptake value; TFR, tendon friction rubs; TTE, transthoracic echocardiography.
See this image and copyright information in PMC

References

    1. Sato S, Fujimoto M, Hasegawa M, et al. Altered blood B lymphocyte homeostasis in systemic sclerosis: Expanded naive B cells and diminished but activated memory B cells. Arthritis Rheumatol 2004;50:1918–27. 10.1002/art.20274 - DOI - PubMed
    1. Ebata S, Yoshizaki A, Oba K, et al. Safety and efficacy of Rituximab in systemic sclerosis (DESIRES): A double-blind, investigator-initiated, randomised, placebo-controlled trial. The Lancet rheumatology 2021;3:e489–97. 10.1016/S2665-9913(21)00107-7 - DOI - PubMed
    1. Maher TM, Tudor VA, Saunders P, et al. Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): A double-blind, double-dummy, randomised, controlled, phase 2B trial. Lancet (London, England) 2023;11:45–54. 10.1016/S2213-2600(22)00359-9 - DOI - PubMed
    1. van Laar JM, Farge D, Sont JK, et al. Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: A randomized clinical trial. Jama 2014;311:2490. 10.1001/jama.2014.6368 - DOI - PubMed
    1. Mougiakakos D, Krönke G, Völkl S, et al. Cd19-targeted CAR T cells in refractory systemic lupus erythematosus. N Engl J Med 2021;385:567–9. 10.1056/NEJMc2107725 - DOI - PubMed

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