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. 2023 Jun;43(3):568-573.
doi: 10.19852/j.cnki.jtcm.20230227.001.

Effects of Traditional Chinese Medicine on the survival of patients with stage I gastric cancer and high-risk factors: a real-world retrospective study

Hou Chao  1 , Zhang Yusen  2 , Yang Die  2 , L I Yifei  2 , Zhang Xiaochun  3 , Liu Yanqing  2   4
Affiliations

Effects of Traditional Chinese Medicine on the survival of patients with stage I gastric cancer and high-risk factors: a real-world retrospective study

Hou Chao et al. J Tradit Chin Med. 2023 Jun.

Abstract

Objective: To investigate the benefits of Traditional Chinese Medicine (TCM) therapy for improving the survival of patients with stage I gastric cancer (GC) and high-risk factors in a real-world setting.

Methods: The clinical data of patients who were diagnosed with stage I GC from March 1, 2012 to October 31, 2020 were collected. Prognostic analysis was performed to explore the high-risk factors that affected the survival of the patients. A Cox multivariate regression model was used to compare the hazard ratios for the mortality risk of patients, especially those with high-risk factors. Kaplan-Meier survival curve and log-rank test were utilized to assess the survival time.

Results: Prognostic analysis demonstrated that female sex, tumor invasion into blood vessels, and Ib stage were independent risk factors. The 1-, 3-, and 5-year survival rates of the TCM group those of the non-TCM group were 100.0% 91.0%, 97.6% 64.5%, and 81.4% 55.5%, respectively. A significant difference in median overall survival (mOS) was found between the two groups (χ = 7.670, = 0.006). Subgroup analysis showed that the mOS of female patients and stage Ib patients in the TCM group were longer than those in the non-TCM group ( ≤ 0.001 and 0.001, respectively).

Conclusions: TCM treatment can improve the survival of patients with stage I GC and high-risk factors.

Keywords: integrative medicine; medicine, Chinese traditional; overall mortality; real-world; stomach neoplasms.

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Figures

Figure 1
Figure 1. Flow diagram of patient selection and grouping
TCM: Traditional Chinese Medicine; GC: gastric cancer.
Figure 2
Figure 2. Comparison of OS and DFS between TCM and non-TCM groups of patients with GC
A: comparison of OS between TCM and non-TCM groups of patients with GC; B: comparison of DFS between TCM and non-TCM groups of patients with GC; C: comparison of OS between TCM and non-TCM groups of patients with stage Ib GC; D: comparison of OS between the TCM and non-TCM groups of female patients with stage I GC. OS: overall survival; DFS: disease-free survival; TCM: Traditional Chinese Medicine; GC: gastric carcinoma.
See this image and copyright information in PMC

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