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Case Reports
. 2023 Dec;43(6):472-478.
doi: 10.1111/neup.12907. Epub 2023 May 5.

Granular cell tumor of the neurohypophysis presenting as a third ventricle mass

Gianluca Lopez  1 , Carlo Pescia  1 , Carlo Galli  2 , Manuela Bramerio  3 , Antonella Tosoni  4 , Manuela Nebuloni  4   5 , Mariarosa Ferrara  6 , Giulio Bertani  7 , Luca Caschera  8 , Fabio Maria Triulzi  8   9 , Marco Locatelli  7   9 , Silvia Tabano  6   9 , Giorgio Alberto Croci  1   9
Affiliations
Case Reports

Granular cell tumor of the neurohypophysis presenting as a third ventricle mass

Gianluca Lopez et al. Neuropathology. 2023 Dec.

Abstract

Granular cell tumors of the neurohypophysis (GCT) are rare benign neoplasms belonging, along with pituicytoma and spindle cell oncocytoma, to the family of TTF1-positive low-grade neoplasms of the posterior pituitary gland. GCT usually present as a solid sellar mass, slowly growing and causing compressive symptoms over time, occasionally with suprasellar extension. They comprise polygonal monomorphous cells with abundant granular cytoplasm, which is ultrastructurally filled with lysosomes. Here we report the case of a GCT presenting as a third ventricle mass, radiologically mimicking chordoid glioma, with aberrant expression of GFAP and Annexin-A, which lends itself as an example of an integrated diagnostic approach to sellar/suprasellar and third ventricle masses.

Keywords: granular cell tumor; pituicytoma; posterior pituitary; third ventricle.

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References

REFERENCES

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