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Editorial
. 2023 Jun 1;146(6):2208-2210.
doi: 10.1093/brain/awad154.

The pathotome and precision health

Kyan Younes  1 , Elizabeth C Mormino  1   2
Affiliations
Editorial

The pathotome and precision health

Kyan Younes et al. Brain. .

Abstract

This scientific commentary refers to ‘Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated’ by Robinson et al. (https://doi.org/10.1093/brain/awad059).

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Conflict of interest statement

E.C.M. has received consulting fees from Eli Lilly and Neurotrack. K.Y. reports no competing interests.

Figures

Figure 1
Figure 1
The person-specific pathotome is a representation of the individual-level heterogeneity of neuropathological findings in neurodegenerative disease. Top right: Robinson and colleagues considered 10 pathological categories and eight clinical diagnoses. Left: Examples of the potential upstream pathways that may drive the pathological changes observed. Bottom right: Three examples of a pathotome. Similar to a fingerprint, each individual has a particular pattern of pathologies affecting different anatomical brain regions to varying degrees. Ab = amyloid-β; AD = Alzheimer’s disease; a-Syn =α-synuclein; CAA = cerebral amyloid angiopathy; CVD = cerebrovascular disease; TDP = transactive response DNA-binding protein; ND = neurodegenerative disease.
See this image and copyright information in PMC

Comment on

References

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