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Case Reports
. 2023 May 4;11(5):e7296.
doi: 10.1002/ccr3.7296. eCollection 2023 May.

Diagnosing, imaging, and successfully treating a debilitating case of Bing-Neel syndrome: A multidisciplinary feat

Robert N Kerley  1   2 , Niamh O'Donnell  2 , Fiona Lynott  2 , Riona Mulcahy  2 , Brian Hennessy  2
Affiliations
Case Reports

Diagnosing, imaging, and successfully treating a debilitating case of Bing-Neel syndrome: A multidisciplinary feat

Robert N Kerley et al. Clin Case Rep. .

Abstract

Key clinical message: We present a case of Bing-Neel syndrome a rare central nervous system lymphoplasmocytic lymphoma associated with Waldenstrom macroglobulinemia. Diagnosis should be considered in the context of unexplained neurological symptoms in the presence of macroglobulinemia.

Abstract: Waldenstroms macroglobulinaemia (WM) is a rare B-cell lymphoma representing ~2% of all hematological malignancies. While most neurological complications of WM are secondary to the overproduction of immunoglobulin M (IgM), Bing-Neel syndrome (BNS) is an extremely rare direct central nervous system (CNS) infiltration by malignant lymphoplasmocytic lymphoma (LPL) cells. Limited information on BNS exists in the literature with sparse case reports and case series. Here, we present a diagnostically challenging BNS case successfully treated with systemic chemoimmunotherapy and ibrutinib, with remarkable clinical response.

Keywords: Bing–Neel syndrome; Waldenstrom macroglobulinemia; diagnostic imaging.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

FIGURE 1
FIGURE 1
MRI whole spine outlining subtle posterior meningeal enhancement at T10 and T11.
See this image and copyright information in PMC

References

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