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. 2023 Apr 19:13:1132369.
doi: 10.3389/fonc.2023.1132369. eCollection 2023.

Epidemiology and survival of cervical cancer in Iran based on national cancer registry data (2008-2014)

Atieh Akbari  1 , Maryam Khayamzadeh  1   2 , Reza Salmanian  1 , Afshin Moradi  1 , Mohammad Esmaeil Akbari  1
Affiliations

Epidemiology and survival of cervical cancer in Iran based on national cancer registry data (2008-2014)

Atieh Akbari et al. Front Oncol. .

Abstract

Background: Cervical cancer (CC) is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in females worldwide, associated with the incidence of human papillomavirus (HPV) infection. The CC incidence is low in Iran, ranking 11th among cancers. This study aimed to estimate the survival rate of CC and the reasons for its low survival rate based on the data retrieved from the Iranian National Cancer Registry System.

Methods: In this retrospective cohort study, data for patients diagnosed with CC from 2008 to 2014 were collected and analyzed. The Kaplan-Meier method was used for survival analysis based on epidemiological and clinical factors.

Results: A total of 5,304 women were diagnosed from March 10, 2008 to March 9, 2014 and 2,423 patients were followed. The mean age of the cases was 51.91 years, and 65.91% were alive. The 5- and 10-year survival rates were 58% and 50%, respectively, with no difference between younger cases with SCC or AC but better survival rates for older patients with SCC.

Conclusions: As a preventable disease, CC is related to biological factors and geographical and sociodemographic indices. Geographical, cultural, and religious behaviors affect the CC incidence and survival. In Iran, the 5-year survival rate ranges from 34% to 70% among different geographic regions. Hence, effective screening based on cultural and sociodemographic issues is recommended.

Keywords: Iran; epidemiology; incidence; survival; uterine cervical neoplasm.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Age distribution of patients with cervical cancer in Iran during 2008-2014.
Figure 2
Figure 2
The 5- and 10-year survival rates of cervical cancer from 2008 to 2014.
Figure 3
Figure 3
The 5- and 10-year survival rates of patients with cervical cancer based on aged groups.
Figure 4
Figure 4
The 5- and 10-year survival rate of patients with cervical cancer based on pathology type.
Figure 5
Figure 5
(A) The 5- and 10-year survival rates of patients with cervical cancer in ≤30 years based on pathology (B) The 5- and 10-year survival rates of patients with cervical cancer in ≥60 years based on pathology.
See this image and copyright information in PMC

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