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. 2023 Apr 13;18(6):45.
doi: 10.3892/mco.2023.2641. eCollection 2023 Jun.

Measurements of target volumes and organs at risk using DW‑MRI in patients with central lung cancer accompanied with atelectasis

Xinli Zhang  1   2 , Tong Liu  3 , Hong Zhang  1 , Mingbin Zhang  3
Affiliations

Measurements of target volumes and organs at risk using DW‑MRI in patients with central lung cancer accompanied with atelectasis

Xinli Zhang et al. Mol Clin Oncol. .

Abstract

Accurate imaging-based tumor delineation is crucial for guiding the radiotherapy treatments of various solid tumors. Currently, several imaging procedures, including diffusion-weighted magnetic resonance imaging (DW-MRI), intensified computed tomography and positron emission tomography are routinely used for targeted tumor delineation. However, the performance of these imaging procedures has not yet been comprehensively evaluated. In order to address this matter, the present study was conducted in an aim to assess the use of DW-MRI in guiding radiotherapy treatments, by comparing its performance to that of other imaging procedures. Specifically, the exposure dosages to organs at risk, including the lungs, heart and spinal mencord, were evaluated using various radiotherapy regimes. The findings of the present study demonstrated that DW-MRI is a non-invasive and cost-effective imaging procedure that can be used to reduce lung exposure doses, minimizing the risk of radiation pneumonitis. The data further demonstrate the immense potential of the DW-MRI procedure in the precision radiotherapy of lung cancers.

Keywords: atelectasis; central lung cancer; diffusion-weighted magnetic resonance imaging; organs at risk; radiotherapy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Magnetic resonance imaging sequences of a 61-year-old female patient with a central lung cancer accompanied with atelectasis. (A) Images from T1 sequence. (B) Images from T2 sequence. (C) Images from DWI sequence. DWI can differentiate tumor (red arrow) from atelectasis (white arrow), and tumor in DWI sequence had a clearer margin than those in T1 and T2 sequences. DWI, diffusion weighted imaging.
Figure 2
Figure 2
DVH from the (A) PlanCT, (B) PlanPET and (C) PlanMRI of a 67-year-old female patient with central lung cancer in right-middle lung. Differences in volume are depicted at every dose under the three plans. The yellow line denotes the left lung, while the right lung, total lung, heart, and spinal cord are respectively represented by the green line (for the right lung), pink line (for the total lung), red line (for the heart) and blue line (for the spinal cord). DVH, dose volume histograms; PlanCT, 3D conformal plans in CT imaging; PlanPET, 3D conformal plans in PET/CT imaging; PlanMRI, 3D conformal plans in MRI imaging; CT, computed tomography; PET, positron emission tomography; MRI, magnetic resonance imaging.
See this image and copyright information in PMC

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