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. 2023 May 3;5(3):dlad053.
doi: 10.1093/jacamr/dlad053. eCollection 2023 Jun.

Mobile colistin resistance mcr-4.3- and mcr-4.6-harbouring plasmids in livestock- and human-retrieved Enterobacterales in the Netherlands

Casper Jamin  1 , Michael S M Brouwer  2 , Kees T Veldman  2 , Erik Beuken  1 , Sandra Witteveen  3 , Fabian Landman  3 , Edou Heddema  4 , Paul H M Savelkoul  1   5 , Lieke van Alphen  1 , Antoni P A Hendrickx  3 ; Dutch CPE Surveillance Study Group
Collaborators, Affiliations

Mobile colistin resistance mcr-4.3- and mcr-4.6-harbouring plasmids in livestock- and human-retrieved Enterobacterales in the Netherlands

Casper Jamin et al. JAC Antimicrob Resist. .
No abstract available

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Figures

Figure 1.
Figure 1.
In silico characterization of mcr-4-containing plasmids. (a) Short-read sequencing-based molecular characteristics of the mcr-4-carrying isolates analysed in this study. (b) Comparison of mcr-4 plasmids from the Netherlands in context with NCBI-retrieved plasmids. The % G + C content and plasmid size in bp is indicated. The presence of mcr-4 alleles and replicons is indicated by squares. Heatmap indicating percentage identity. (c) Alignment of all mcr-4-harbouring plasmids from the Netherlands with one E. kobei plasmid (pIB2020_ColE_MCR, CP059482.1) from Italy using CLC Genomics Workbench (v22.0.2). Plasmids were rotated and the mcr-4 allele was set as starting point for comparison.
See this image and copyright information in PMC

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