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. 2023 Aug;270(8):4024-4030.
doi: 10.1007/s00415-023-11697-z. Epub 2023 May 8.

Microvascular involvement in migraine: an optical coherence tomography angiography study

Marina Romozzi #  1   2 , Giovanni Cuffaro #  3 , Eleonora Rollo  1   2 , Roberta Mattei  3 , Sofia Marcelli  3 , Stanislao Rizzo  3   4 , Paolo Calabresi  1   2 , Serenella Servidei  1   5 , Gustavo Savino #  3   4 , Catello Vollono #  6   7
Affiliations

Microvascular involvement in migraine: an optical coherence tomography angiography study

Marina Romozzi et al. J Neurol. 2023 Aug.

Abstract

Objective: The aim of this study was to evaluate the microvasculature of the macula and the optic nerve in patients affected by migraine with aura (MA) and without aura (MO) by optical coherence tomography angiography (OCTA), comparing the findings with healthy controls (HC).

Methods: We collected data from ocular and orthotic examinations, including eye motility, intraocular pressure measurement, best-corrected visual acuity (BCVA) measurement, objective refraction measurement, fundus examination, macular and optic disk OCTA examination. All subjects were imaged with solix fullrange OCT. The following OCTA parameters were recorded: macular vessel density (VD), inside disc VD, peripapillary VD, disc whole image VD, fovea choriocapillaris VD, fovea VD, parafovea VD, peripapillary thickness, fovea thickness, parafovea thickness, macular full retinal thickness, and foveal avascular zone (FAZ) parameters. Clinical and demographical data about migraine patients were collected by a neurologist.

Results: We included 56 eyes from 28 patients with a diagnosis of MO, 32 eyes from 16 patients with a diagnosis of MA, and 32 eyes from 16 HC subjects. The FAZ area was 0.230 ± 0.099 mm2 in the MO group, 0.248 ± 0.091 mm2 in the MA group and 0.184 ± 0.061 mm2 in the control group. The FAZ area was significantly larger in the MA group than in the HC group (p = 0.007). The foveal choriocapillaris VD was significantly lower in MA patients (63.6 ± 2.49%) when compared with MO patients (65.27 ± 3.29%) (p = 0.02).

Conclusion: An impairment of retinal microcirculation can be detected in patients with MA, as demonstrated by the enlargement of FAZ. Moreover, the study of choroid circulation may reveal microvascular damage in patients with migraine with aura. OCTA is a useful non-invasive screening tool for the detection of microcirculatory disturbance in patients with migraine.

Keywords: Aura; FAZ; Migraine; OCTA; Retinal vessel density; Retinopathy.

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