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. 2023 Aug 1;80(8):769-770.
doi: 10.1001/jamaneurol.2023.1059.

A Call to Action to Address Sex Differences in Alzheimer Disease Clinical Trials

Rachel F Buckley  1   2 , Jessica Gong  3   4 , Mark Woodward  3   4
Affiliations

A Call to Action to Address Sex Differences in Alzheimer Disease Clinical Trials

Rachel F Buckley et al. JAMA Neurol. .
No abstract available

Plain language summary

This Viewpoint calls for comprehensive investigations into sex differences associated with treatments in existing Alzheimer disease and integration into future Alzheimer disease and related dementia clinical trials.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Woodward reported personal fees from Amgen Consultancy and personal fees from Freeline Consultancy outside the submitted work. No other disclosures were reported.

References

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    1. Budd Haeberlein S, Aisen PS, Barkhof F, et al. Two randomized phase 3 studies of aducanumab in early Alzheimer’s disease. J Prev Alzheimers Dis. 2022;9(2):197–210. doi: 10.14283/jpad.2022.30 - DOI - PubMed
    1. Buckley RF, O’Donnell A, McGrath ER, et al. Menopause status moderates sex differences in tau burden: a Framingham PET Study. Ann Neurol. 2022;92(1):11–22.doi: 10.1002/ana.26382 - DOI - PMC - PubMed
    1. Buckley RF, Mormino EC, Rabin JS, et al. Sex differences in the association of global amyloid and regional tau deposition measured by positron emission tomography in clinically normal older adults. JAMA Neurol. 2019;76(5):542–551. doi: 10.1001/jamaneurol.2018.4693 - DOI - PMC - PubMed
    1. Hohman TJ, Dumitrescu L, Barnes LL, et al. ; Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative. Sex-specific association of apolipoprotein E with cerebrospinal fluid levels of tau. JAMA Neurol. 2018;75(8):989–998. doi: 10.1001/jamaneurol.2018.0821 - DOI - PMC - PubMed