Improving stem cell-derived pancreatic islets using single-cell multi-inferred regulomes
- PMID: 37160100
- DOI: 10.1016/j.devcel.2023.04.008
Improving stem cell-derived pancreatic islets using single-cell multi-inferred regulomes
Abstract
In this issue of Developmental Cell, Zhu et al. provide integrated data from single-cell/nuclei RNAseq and chromatin accessibility (ATAC) across both a multistaged differentiation protocol-deriving pancreatic islets from hESCs and primary islets. This important resource could be leveraged for optimizing the differentiation and maturation of pancreatic islet cells from hESCs.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare they have no conflict of interest.
Comment on
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Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes.Dev Cell. 2023 May 8;58(9):727-743.e11. doi: 10.1016/j.devcel.2023.03.011. Epub 2023 Apr 10. Dev Cell. 2023. PMID: 37040771 Free PMC article.
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