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. 2023 May 9;23(1):86.
doi: 10.1186/s12894-023-01222-9.

Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population

Fei Wang #  1 , Defan Luo #  2 , Jianxiang Chen  3 , Cuiqing Pan  1 , Zhongyao Wang  1 , Housheng Fu  1 , Jianbing Xu  1 , Meng Yang  4 , Shaowei Mo  5 , Liying Zhuang  6 , Weifu Wang  7
Affiliations

Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population

Fei Wang et al. BMC Urol. .

Abstract

Background: Lifelong premature ejaculation (LPE) is one of the most common ejaculatory dysfunctions in men. The serotonin (5-HT) synthesis rate-limiting enzyme (TPH2) and receptor (HTR1A) in the 5-HT regulatory system may play a key role in the pathogenesis of LPE. However, there are few studies on the effects of TPH2 and HTR1A polymorphisms on LPE risk. We speculated that TPH2 and HTR1A polymorphisms may affect the occurrence and development of LPE in the Chinese Han population.

Methods: In this study, 91 patients with LPE and 362 normal controls aged 18 to 64 years were enrolled in the male urology department of Hainan General Hospital in China from January 2016 to December 2018. The SNPs in HTR1A and TPH2, which are related to 5-HT regulation, were selected as indexes to genotype the collected blood samples of participants. Logistic regression was used to analyze the correlation between SNPs of HTR1A and TPH2 with LPE susceptibility, as well as the relationship with leptin, 5-HT and folic acid levels.

Results: The results revealed that HTR1A-rs6295 increased LPE risk in recessive model. Rs11178996 in TPH2 significantly reduced susceptibility to LPE in allelic (odds ratio (OR) = 0.68, 95% confidence interval (95% CI) = 0.49-0.96, p = 0.027), codominant (OR = 0.58, 95% CI = 0.35-0.98, p = 0.040), dominant (OR = 0.58, 95% CI = 0.36-0.92, p = 0.020), and additive (OR = 0.71, 95% CI = 0.52-0.98, p = 0.039) models. Grs11179041Trs10879352 could reduce the risk of LPE (OR = 0.44, 95% CI = 0.22-0.90, p = 0.024) by haplotype analysis.

Conclusion: HTR1A-rs6295 and TPH2-rs11178996 are associated with LPE risk in the Chinese Han population based on the finding of this study.

Keywords: 5-hydroxytryptamine (5-HT); Case-control study; HTR1A; Lifelong premature ejaculation (LPE); Single nucleotide polymorphism (SNP); TPH2.

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Conflict of interest statement

The authors declared that they have no conflicts of interest.

The authors declare no competing interests.">

Figures

Fig. 1
Fig. 1
Haplotype block map of HTR1A SNPs. Block 1 includes rs878567 and rs6294 with D’ = 1 for the corresponding variants
Fig. 2
Fig. 2
Haplotype block map of TPH2 SNPs. Block 1 includes rs10879346 and rs1386492 with D’ = 1 for the corresponding variants. Block 2 includes rs11179023 and rs7305115 with D’ = 1 for the corresponding variants. Block 3 includes rs11179041 and rs10879352 with D’ = 1 for the corresponding variants
See this image and copyright information in PMC

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