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. 2023 Jul;114(1):23-24.
doi: 10.1002/cpt.2921. Epub 2023 May 10.

Implementation of DPYD Genotyping in Admixed American Populations: Brazil as a Model Case

Guilherme Suarez-Kurtz  1 , Vanessa Câmara Fernandes  1 , Anna Beatriz Ribeiro Elias  1
Affiliations

Implementation of DPYD Genotyping in Admixed American Populations: Brazil as a Model Case

Guilherme Suarez-Kurtz et al. Clin Pharmacol Ther. 2023 Jul.
No abstract available

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References

    1. White, C. et al. Dihydropyrimidine dehydrogenase deficiency and implementation of upfront DPYD genotyping. Clin. Pharmacol. Ther. 112, 791-802 (2022).
    1. Naslavsky, M.S. et al. Whole-genome sequencing of 1,171 elderly admixed individuals from São Paulo, Brazil. Nat. Commun. 13, 1004 (2022 Mar 4).
    1. Botton, M.R., Hentschke-Lopes, M. & Matte, U. Frequency of DPYD gene variants and phenotype inference in a southern Brazilian population. Ann Hum Genet. 86, 102-107 (2022).
    1. Pena, S.D. et al. The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected. PLoS One. 6, e17063 (2011).
    1. Cunha-Junior, G.F. et al. Prevalence of the DPYD variant (Y186C) in Brazilian individuals of African ancestry. Cancer Chemother. Pharmacol. 84, 1359-1363 (2019).

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