Elucidating molecular mechanisms that alleviate cardiac microvascular dysfunction in diabetes: The potential benefit of targeting mitophagy and mitochondrial integrity

Affiliations

Editorial

William B Horton. Acta Physiol (Oxf). 2023 Jul.

. 2023 Jul;238(3):e13983.

doi: 10.1111/apha.13983. Epub 2023 May 19.

¹ Division of Endocrinology and Metabolism, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

No abstract available

Comment on

L-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways.
Li S, Liu M, Chen J, Chen Y, Yin M, Zhou Y, Li Q, Xu F, Li Y, Yan X, Xia Y, Chen A, Lu D, Li C, Shen L, Chen Z, Qian J, Ge J. Li S, et al. Acta Physiol (Oxf). 2023 Jul;238(3):e13975. doi: 10.1111/apha.13975. Epub 2023 Apr 30. Acta Physiol (Oxf). 2023. PMID: 37042471

1. Li S, Liu M, Chen J, et al. L-carnitine alleviates cardiac microvascular dysfunction in diabetic cardiomyopathy by enhancing PINK1-Parkin-dependent mitophagy through the CPT1a-PHB2-PARL pathways. Acta Physiol (Oxf). 2023;e13975.
1. Liu M, Wu Y. Role of mitophagy in coronary heart disease: targeting the mitochondrial dysfunction and inflammatory regulation. Front Cardiovasc Med. 2022;9:819454.
1. Luan Y, Luan Y, Feng Q, Chen X, Ren KD, Yang Y. Emerging role of mitophagy in the heart: therapeutic potentials to modulate mitophagy in cardiac diseases. Oxid Med Cell Longev. 2021;2021:3259963.
1. Wu D, Ji H, Du W, Ren L, Qian G. Mitophagy alleviates ischemia/reperfusion-induced microvascular damage through improving mitochondrial quality control. Bioengineered. 2022;13(2):3596-3607.
1. Sivitz WI, Yorek MA. Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid Redox Signal. 2010;12(4):537-577.