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Comment
. 2023 May 9;56(5):900-902.
doi: 10.1016/j.immuni.2023.04.007.

Macrophages show up in style when Th2 lymphocytes organize their homecoming

Xin Li  1 , Claudia V Jakubzick  2
Affiliations
Comment

Macrophages show up in style when Th2 lymphocytes organize their homecoming

Xin Li et al. Immunity. .

Abstract

Monocytes can differentiate into tissue-resident pleural macrophages, but the mechanisms underlying this process are not yet fully understood. In this issue of Immunity, Finlay et al.1 show that Th2 cytokines promote this differentiation in resistant mice infected with Litomosoides sigmodontis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.. Uncovering the mechanism behind Litomosoides sigmodontis resistance: Type 2 cytokine-induced pleural macrophages and the transition from monocytes to M(IL-4) LCMs in C57BL/6 mice
Small-cavity macrophages (SCMs); converting cavity macrophages (CCMs); large-cavity macrophages (LCMs); IL-4Rα-dependent large-cavity macrophages (M[IL-4] LCMs); type 2 helper T cells (Th2); retinoic acid (RA). Created with BioRender.com.
See this image and copyright information in PMC

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References

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