Propionate primes the DC pump in neonates

Tyler A Rice¹, Liza Konnikova²

Affiliations

¹ Department of Pediatrics, Yale School of Medicine, New Haven, CT 06510, USA.
² Department of Pediatrics, Yale School of Medicine, New Haven, CT 06510, USA; Department of Obstetrics, Gynecology and Reproductive Science, Yale School of Medicine, New Haven, CT 06510, USA; Program of Translational Biomedicine, Yale School of Medicine, New Haven, CT 06510, USA; Program of Human and Translational Immunology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: liza.konnikova@yale.edu.

PMID: 37163990
DOI: 10.1016/j.immuni.2023.04.006

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Propionate primes the DC pump in neonates

Tyler A Rice et al. Immunity. 2023.

Free article

. 2023 May 9;56(5):903-905.

doi: 10.1016/j.immuni.2023.04.006.

Authors

Tyler A Rice¹, Liza Konnikova²

Affiliations

¹ Department of Pediatrics, Yale School of Medicine, New Haven, CT 06510, USA.
² Department of Pediatrics, Yale School of Medicine, New Haven, CT 06510, USA; Department of Obstetrics, Gynecology and Reproductive Science, Yale School of Medicine, New Haven, CT 06510, USA; Program of Translational Biomedicine, Yale School of Medicine, New Haven, CT 06510, USA; Program of Human and Translational Immunology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: liza.konnikova@yale.edu.

PMID: 37163990
DOI: 10.1016/j.immuni.2023.04.006

Abstract

The protective benefits of breastmilk are well-appreciated, yet lack mechanistic detail. In this issue of Immunity, Sikder et al. reveal how breastmilk-microbiota-derived propionate induces Flt3L expression, dendritic cell maturation, regulatory T cell recruitment, and antiviral immunity in the lung.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection.
Sikder MAA, Rashid RB, Ahmed T, Sebina I, Howard DR, Ullah MA, Rahman MM, Lynch JP, Curren B, Werder RB, Simpson J, Bissell A, Morrison M, Walpole C, Radford KJ, Kumar V, Woodruff TM, Ying TH, Ali A, Kaiko GE, Upham JW, Hoelzle RD, Cuív PÓ, Holt PG, Dennis PG, Phipps S. Sikder MAA, et al. Immunity. 2023 May 9;56(5):1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002. Epub 2023 Mar 31. Immunity. 2023. PMID: 37003256

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Propionate primes the DC pump in neonates

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Propionate primes the DC pump in neonates

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