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Comment
. 2023 May 9;56(5):906-908.
doi: 10.1016/j.immuni.2023.04.016.

Decoding nociceptor-DC dialogues

Theo Crosson  1 , Sebastien Talbot  2
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Comment

Decoding nociceptor-DC dialogues

Theo Crosson et al. Immunity. .
Free article

Abstract

Neuro-immune interactions link physiological and immune responses in host defense. Hanč et al.1 report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a "sentinel" DC program via the neuropeptide calcitonin gene-related peptide (CGRP), and enhance DC inflammatory responses through direct connections. These neuroimmune units integrate nociceptors' rapid responsiveness with DCs' immune coordination, functioning as an advanced warning system.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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