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Review
. 2023 Jun:186:104020.
doi: 10.1016/j.critrevonc.2023.104020. Epub 2023 May 8.

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer

Daniele Campa  1 , Manuel Gentiluomo  2 , Angelika Stein  3 , Mateus Nóbrega Aoki  4 , Martin Oliverius  5 , Ludmila Vodičková  6 , Krzysztof Jamroziak  7 , George Theodoropoulos  8 , Claudio Pasquali  9 , William Greenhalf  10 , Paolo Giorgio Arcidiacono  11 , Faik Uzunoglu  12 , Raffaele Pezzilli  13 , Claudio Luchini  14 , Marta Puzzono  15 , Martin Loos  16 , Matteo Giaccherini  2 , Verena Katzke  17 , Andrea Mambrini  18 , Edita Kiudeliene  19 , Kauffmann Emanuele Federico  20 , Julia Johansen  21 , Tamás Hussein  22 , Beatrice Mohelnikova-Duchonova  23 , Casper H J van Eijck  24 , Hermann Brenner  25 , Riccardo Farinella  2 , Juan Sainz Pérez  26 , Martin Lovecek  27 , Markus W Büchler  16 , Viktor Hlavac  28 , Jakob R Izbicki  12 , Thilo Hackert  16 , Roger Chammas  29 , Alessandro Zerbi  30 , Rita Lawlor  31 , Alessio Felici  2 , Mara Götz  12 , Gabriele Capurso  32 , Laura Ginocchi  18 , Maria Gazouli  33 , Juozas Kupcinskas  19 , Giulia Martina Cavestro  15 , Pavel Vodicka  6 , Stefania Moz  34 , John P Neoptolemos  16 , Lumir Kunovsky  35 , Stig E Bojesen  21 , Silvia Carrara  36 , Domenica Gioffreda  37 , Egidijus Morkunas  19 , Olga Abian  38 , Stefania Bunduc  39 , Daniela Basso  40 , Ugo Boggi  20 , Barbara Wlodarczyk  41 , Andrea Szentesi  42 , Giuseppe Vanella  32 , Inna Chen  21 , Maarten F Bijlsma  43 , Vytautas Kiudelis  19 , Stefano Landi  2 , Ben Schöttker  44 , Chiara Corradi  2 , Nathalia Giese  16 , Rudolf Kaaks  17 , Giulia Peduzzi  2 , Péter Hegyi  45 , Luca Morelli  46 , Niccolò Furbetta  46 , Pavel Soucek  28 , Anna Latiano  37 , Renata Talar-Wojnarowska  41 , Sidsel C Lindgaard  21 , Frederike Dijk  47 , Anna Caterina Milanetto  9 , Francesca Tavano  37 , Klara Cervena  48 , Bálint Erőss  49 , Sabrina G Testoni  11 , Judith H E Verhagen-Oldenampsen  50 , Ewa Małecka-Wojciesko  41 , Eithne Costello  10 , Roberto Salvia  51 , Evaristo Maiello  52 , Stefano Ermini  53 , Cosimo Sperti  54 , Bernd Holleczek  55 , Francesco Perri  37 , Jurgita Skieceviciene  19 , Livia Archibugi  32 , Maurizio Lucchesi  18 , Cosmeri Rizzato  56 , Federico Canzian  57
Affiliations
Free article
Review

The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer

Daniele Campa et al. Crit Rev Oncol Hematol. 2023 Jun.
Free article

Abstract

Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

Keywords: Chronic pancreatitis; Consortium; Genetic epidemiology; Intraductal papillary mucinous neoplasms; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Pancreatic neuroendocrine tumors.

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Conflict of interest statement

Declaration of Competing Interest MFB has received research funding from Celgene, Frame Therapeutics, and Lead Pharma, and has acted as a consultant to Servier.

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