Review
doi: 10.1016/j.critrevonc.2023.104020.
Epub 2023 May 8.
The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer
Daniele Campa
1
, Manuel Gentiluomo
2
, Angelika Stein
3
, Mateus Nóbrega Aoki
4
, Martin Oliverius
5
, Ludmila Vodičková
6
, Krzysztof Jamroziak
7
, George Theodoropoulos
8
, Claudio Pasquali
9
, William Greenhalf
10
, Paolo Giorgio Arcidiacono
11
, Faik Uzunoglu
12
, Raffaele Pezzilli
13
, Claudio Luchini
14
, Marta Puzzono
15
, Martin Loos
16
, Matteo Giaccherini
2
, Verena Katzke
17
, Andrea Mambrini
18
, Edita Kiudeliene
19
, Kauffmann Emanuele Federico
20
, Julia Johansen
21
, Tamás Hussein
22
, Beatrice Mohelnikova-Duchonova
23
, Casper H J van Eijck
24
, Hermann Brenner
25
, Riccardo Farinella
2
, Juan Sainz Pérez
26
, Martin Lovecek
27
, Markus W Büchler
16
, Viktor Hlavac
28
, Jakob R Izbicki
12
, Thilo Hackert
16
, Roger Chammas
29
, Alessandro Zerbi
30
, Rita Lawlor
31
, Alessio Felici
2
, Mara Götz
12
, Gabriele Capurso
32
, Laura Ginocchi
18
, Maria Gazouli
33
, Juozas Kupcinskas
19
, Giulia Martina Cavestro
15
, Pavel Vodicka
6
, Stefania Moz
34
, John P Neoptolemos
16
, Lumir Kunovsky
35
, Stig E Bojesen
21
, Silvia Carrara
36
, Domenica Gioffreda
37
, Egidijus Morkunas
19
, Olga Abian
38
, Stefania Bunduc
39
, Daniela Basso
40
, Ugo Boggi
20
, Barbara Wlodarczyk
41
, Andrea Szentesi
42
, Giuseppe Vanella
32
, Inna Chen
21
, Maarten F Bijlsma
43
, Vytautas Kiudelis
19
, Stefano Landi
2
, Ben Schöttker
44
, Chiara Corradi
2
, Nathalia Giese
16
, Rudolf Kaaks
17
, Giulia Peduzzi
2
, Péter Hegyi
45
, Luca Morelli
46
, Niccolò Furbetta
46
, Pavel Soucek
28
, Anna Latiano
37
, Renata Talar-Wojnarowska
41
, Sidsel C Lindgaard
21
, Frederike Dijk
47
, Anna Caterina Milanetto
9
, Francesca Tavano
37
, Klara Cervena
48
, Bálint Erőss
49
, Sabrina G Testoni
11
, Judith H E Verhagen-Oldenampsen
50
, Ewa Małecka-Wojciesko
41
, Eithne Costello
10
, Roberto Salvia
51
, Evaristo Maiello
52
, Stefano Ermini
53
, Cosimo Sperti
54
, Bernd Holleczek
55
, Francesco Perri
37
, Jurgita Skieceviciene
19
, Livia Archibugi
32
, Maurizio Lucchesi
18
, Cosmeri Rizzato
56
, Federico Canzian
57
Affiliations
Affiliations
- 1 Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy. Electronic address: daniele.campa@unipi.it.
- 2 Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy.
- 3 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 4 Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil.
- 5 Department of Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
- 6 Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, 1st Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic; Biomedical Centre, Faculty of Medicine in Pilsen Charles University, Pilsen, Czech Republic.
- 7 Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
- 8 First Department of Propaedeutic Surgery, Hippocration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
- 9 Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 3, Padova, Italy.
- 10 Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom.
- 11 Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientic Institute, Milan, Italy.
- 12 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 13 Potenza Medica County Association, Potenza, Italy.
- 14 Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.
- 15 Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
- 16 Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
- 17 Division of Cancer Epidemiology C020, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 18 Oncological Department Massa Carrara, Azienda USL Toscana Nord Ovest, Carrara, Italy.
- 19 Institute for Digestive Research and Gastroenterology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania.
- 20 Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy.
- 21 Departments of Oncology and Medicine, Copenhagen University Hospital, Herlev, Denmark.
- 22 Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary.
- 23 Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
- 24 Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
- 25 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 26 Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Complejo Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain; Department of Immunology, University of Granada, Granada, Spain.
- 27 Department of Surgery I, University Hospital Olomouc, Olomouc, Czech Republic.
- 28 Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
- 29 Center for Translational Research in Oncology (LIM24), Departamento de Radiologia e Oncologia, Instituto Do Câncer Do Estado de São Paulo (ICESP), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil.
- 30 Pancreatic Unit, IRCCS Humanitas Research Hospital, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
- 31 ARC-Net Research Center, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.
- 32 Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy; Digestive and Liver Disease Unit, Sant' Andrea Hospital, Rome, Italy.
- 33 Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
- 34 Azienda Ospedale-Università di Padova Medicina di Laboratorio, Padova, Italy.
- 35 Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Gastroenterology and Digestive Endoscopy, Masaryk Memorial Cancer Institute, Brno, Czech Republic; 2nd Department of Internal Medicine - Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
- 36 Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy.
- 37 Division of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
- 38 Instituto BIFI-Universidad de Zaragoza, Zaragoza, Spain.
- 39 Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center for Digestive Diseases and Liver Transplant, Fundeni Clinical Insitute, Bucharest, Romania.
- 40 Dept. of Medicine, University of Padova Medicina di Laboratorio, Padova, Italy.
- 41 Dept of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
- 42 Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
- 43 Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Oncode Institute, Amsterdam, the Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, the Netherlands.
- 44 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 45 Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, Szeged, Hungary.
- 46 General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
- 47 Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Pathology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
- 48 Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, 1st Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic.
- 49 Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
- 50 Department of Pulmonary diseases, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
- 51 Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
- 52 Department of Oncology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
- 53 Meyer Children's Hospital IRCCS, Florence, Italy.
- 54 Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 1, Padova, Italy.
- 55 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Saarland Cancer Registry, Saarbrücken, Germany.
- 56 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
- 57 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: f.canzian@dkfz.de.
- PMID: 37164172
- DOI: 10.1016/j.critrevonc.2023.104020
Item in Clipboard
Review
The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer
Daniele Campa et al.
Crit Rev Oncol Hematol.
2023 Jun.
Free article
Display options
Format
doi: 10.1016/j.critrevonc.2023.104020.
Epub 2023 May 8.
Authors
Daniele Campa
1
, Manuel Gentiluomo
2
, Angelika Stein
3
, Mateus Nóbrega Aoki
4
, Martin Oliverius
5
, Ludmila Vodičková
6
, Krzysztof Jamroziak
7
, George Theodoropoulos
8
, Claudio Pasquali
9
, William Greenhalf
10
, Paolo Giorgio Arcidiacono
11
, Faik Uzunoglu
12
, Raffaele Pezzilli
13
, Claudio Luchini
14
, Marta Puzzono
15
, Martin Loos
16
, Matteo Giaccherini
2
, Verena Katzke
17
, Andrea Mambrini
18
, Edita Kiudeliene
19
, Kauffmann Emanuele Federico
20
, Julia Johansen
21
, Tamás Hussein
22
, Beatrice Mohelnikova-Duchonova
23
, Casper H J van Eijck
24
, Hermann Brenner
25
, Riccardo Farinella
2
, Juan Sainz Pérez
26
, Martin Lovecek
27
, Markus W Büchler
16
, Viktor Hlavac
28
, Jakob R Izbicki
12
, Thilo Hackert
16
, Roger Chammas
29
, Alessandro Zerbi
30
, Rita Lawlor
31
, Alessio Felici
2
, Mara Götz
12
, Gabriele Capurso
32
, Laura Ginocchi
18
, Maria Gazouli
33
, Juozas Kupcinskas
19
, Giulia Martina Cavestro
15
, Pavel Vodicka
6
, Stefania Moz
34
, John P Neoptolemos
16
, Lumir Kunovsky
35
, Stig E Bojesen
21
, Silvia Carrara
36
, Domenica Gioffreda
37
, Egidijus Morkunas
19
, Olga Abian
38
, Stefania Bunduc
39
, Daniela Basso
40
, Ugo Boggi
20
, Barbara Wlodarczyk
41
, Andrea Szentesi
42
, Giuseppe Vanella
32
, Inna Chen
21
, Maarten F Bijlsma
43
, Vytautas Kiudelis
19
, Stefano Landi
2
, Ben Schöttker
44
, Chiara Corradi
2
, Nathalia Giese
16
, Rudolf Kaaks
17
, Giulia Peduzzi
2
, Péter Hegyi
45
, Luca Morelli
46
, Niccolò Furbetta
46
, Pavel Soucek
28
, Anna Latiano
37
, Renata Talar-Wojnarowska
41
, Sidsel C Lindgaard
21
, Frederike Dijk
47
, Anna Caterina Milanetto
9
, Francesca Tavano
37
, Klara Cervena
48
, Bálint Erőss
49
, Sabrina G Testoni
11
, Judith H E Verhagen-Oldenampsen
50
, Ewa Małecka-Wojciesko
41
, Eithne Costello
10
, Roberto Salvia
51
, Evaristo Maiello
52
, Stefano Ermini
53
, Cosimo Sperti
54
, Bernd Holleczek
55
, Francesco Perri
37
, Jurgita Skieceviciene
19
, Livia Archibugi
32
, Maurizio Lucchesi
18
, Cosmeri Rizzato
56
, Federico Canzian
57
Affiliations
- 1 Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy. Electronic address: daniele.campa@unipi.it.
- 2 Unit of Genetic, Department of Biology, University of Pisa, Pisa, Italy.
- 3 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 4 Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil.
- 5 Department of Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
- 6 Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, 1st Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic; Biomedical Centre, Faculty of Medicine in Pilsen Charles University, Pilsen, Czech Republic.
- 7 Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
- 8 First Department of Propaedeutic Surgery, Hippocration General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
- 9 Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 3, Padova, Italy.
- 10 Liverpool Experimental Cancer Medicine Centre, University of Liverpool, Liverpool, United Kingdom.
- 11 Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientic Institute, Milan, Italy.
- 12 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
- 13 Potenza Medica County Association, Potenza, Italy.
- 14 Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.
- 15 Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
- 16 Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
- 17 Division of Cancer Epidemiology C020, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 18 Oncological Department Massa Carrara, Azienda USL Toscana Nord Ovest, Carrara, Italy.
- 19 Institute for Digestive Research and Gastroenterology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania.
- 20 Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy.
- 21 Departments of Oncology and Medicine, Copenhagen University Hospital, Herlev, Denmark.
- 22 Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary.
- 23 Department of Oncology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
- 24 Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
- 25 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 26 Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Complejo Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain; Department of Immunology, University of Granada, Granada, Spain.
- 27 Department of Surgery I, University Hospital Olomouc, Olomouc, Czech Republic.
- 28 Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
- 29 Center for Translational Research in Oncology (LIM24), Departamento de Radiologia e Oncologia, Instituto Do Câncer Do Estado de São Paulo (ICESP), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil.
- 30 Pancreatic Unit, IRCCS Humanitas Research Hospital, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
- 31 ARC-Net Research Center, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.
- 32 Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy; Digestive and Liver Disease Unit, Sant' Andrea Hospital, Rome, Italy.
- 33 Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
- 34 Azienda Ospedale-Università di Padova Medicina di Laboratorio, Padova, Italy.
- 35 Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Gastroenterology and Digestive Endoscopy, Masaryk Memorial Cancer Institute, Brno, Czech Republic; 2nd Department of Internal Medicine - Gastroenterology and Geriatrics, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
- 36 Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy.
- 37 Division of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
- 38 Instituto BIFI-Universidad de Zaragoza, Zaragoza, Spain.
- 39 Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center for Digestive Diseases and Liver Transplant, Fundeni Clinical Insitute, Bucharest, Romania.
- 40 Dept. of Medicine, University of Padova Medicina di Laboratorio, Padova, Italy.
- 41 Dept of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
- 42 Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
- 43 Center for Experimental and Molecular Medicine, Laboratory of Experimental Oncology and Radiobiology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands; Oncode Institute, Amsterdam, the Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, the Netherlands.
- 44 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 45 Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, Szeged, Hungary.
- 46 General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
- 47 Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Pathology, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands.
- 48 Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, 1st Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic.
- 49 Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
- 50 Department of Pulmonary diseases, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
- 51 Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
- 52 Department of Oncology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
- 53 Meyer Children's Hospital IRCCS, Florence, Italy.
- 54 Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 1, Padova, Italy.
- 55 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Saarland Cancer Registry, Saarbrücken, Germany.
- 56 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
- 57 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: f.canzian@dkfz.de.
- PMID: 37164172
- DOI: 10.1016/j.critrevonc.2023.104020
Item in Clipboard
Display options
Format
Abstract
Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.
Keywords: Chronic pancreatitis; Consortium; Genetic epidemiology; Intraductal papillary mucinous neoplasms; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Pancreatic neuroendocrine tumors.
Copyright © 2023. Published by Elsevier B.V.
Conflict of interest statement
Declaration of Competing Interest MFB has received research funding from Celgene, Frame Therapeutics, and Lead Pharma, and has acted as a consultant to Servier.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
