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Comment
. 2023 Oct;20(10):1098-1100.
doi: 10.1038/s41423-023-01033-w. Epub 2023 May 10.

The immune hunger games: the effects of fasting on monocytes

Jorge Domínguez-Andrés  1 , Holger Reinecke  2 , Yahya Sohrabi  3   4   5
Affiliations
Comment

The immune hunger games: the effects of fasting on monocytes

Jorge Domínguez-Andrés et al. Cell Mol Immunol. 2023 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Monocyte dynamics during fasting and refeeding. The figure illustrates the key stages of monocyte behavior in response to fasting and refeeding. In the baseline condition (yellow), monocytes circulate in the bloodstream, and hematopoiesis occurs in the bone marrow. During fasting (green), monocytes migrate back to the bone marrow (BM). Increased number of cells in MB deacreases hematopoiesis. Upon refeeding (red), monocytes are remobilized from the bone marrow into the circulation and hematopoiesis resumes. Arrows indicate the direction of events across the different stages. The figure was created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Monocytes re-enter the bone marrow during fasting and alter the host response to infection.
    Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, D'Souza D, McAlpine CS, Halle L, Poller WC, Chan CT, He S, Mindur JE, Kiss MG, Singh S, Anzai A, Iwamoto Y, Kohler RH, Chetal K, Sadreyev RI, Weissleder R, Kim-Schulze S, Merad M, Nahrendorf M, Swirski FK. Janssen H, et al. Immunity. 2023 Apr 11;56(4):783-796.e7. doi: 10.1016/j.immuni.2023.01.024. Epub 2023 Feb 23. Immunity. 2023. PMID: 36827982 Free PMC article.

References

    1. Janssen H, Kahles F, Liu D, Downey J, Koekkoek LL, Roudko V, et al. Monocytes re-enter the bone marrow during fasting and alter the host response to infection. Immunity. 2023;56:783–96.e7. doi: 10.1016/j.immuni.2023.01.024. - DOI - PMC - PubMed
    1. Poller WC, Downey J, Mooslechner AA, Khan N, Li L, Chan CT, et al. Brain motor and fear circuits regulate leukocytes during acute stress. Nature. 2022;607:578–84. doi: 10.1038/s41586-022-04890-z. - DOI - PMC - PubMed
    1. Sohrabi Y, Reinecke H, Soehnlein O. Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation. Signal Transduct Target Ther. 2022;7:249. doi: 10.1038/s41392-022-01121-9. - DOI - PMC - PubMed
    1. Vasamsetti SB, Florentin J, Coppin E, Stiekema LCA, Zheng KH, Nisar MU, et al. Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation. Immunity. 2018;49:93–106.e7. doi: 10.1016/j.immuni.2018.05.004. - DOI - PMC - PubMed
    1. Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, et al. Dietary intake regulates the circulating inflammatory monocyte pool. Cell. 2019;178:1102–14.e17. doi: 10.1016/j.cell.2019.07.050. - DOI - PMC - PubMed

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