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. 1979 Mar;7(3):257-66.
doi: 10.1111/j.1365-2125.1979.tb00930.x.

The metabolism of [14C]-debrisoquine in man

J R Idle, A Mahgoub, M M Angelo, L G Dring, R Lancaster, R L Smith

The metabolism of [14C]-debrisoquine in man

J R Idle et al. Br J Clin Pharmacol. 1979 Mar.

Abstract

1 The synthesis of [14C]-debrisoquine hydrochloride and 4-hydroxy-debrisoquine sulphate is described. 2 The metabolic fate and excretion profile in both urine and faeces of 14C-labelled debrisoquine was studied in five healthy human subjects. 3 Investigations showed that the drug is well-absorbed after a single oral dose of 32 mg and quantitatively eliminated from the body within three days. 4 4-Hydroxy-debrisoquine is the major metabolite of debrisoquine, although significant amounts of 5-,6-, 7- and 8-hydroxy-debrisoquine are also formed. 5 Electron-capture gas chromatography is a useful method for measuring debrisoquine and its five hydroxylated metabolites in urine at the pg level.

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References

    1. J Med Chem. 1965 Jan;8:125-6 - PubMed
    1. J Pharm Pharmacol. 1952 Sep;4(9):631-5 - PubMed
    1. Cancer Res. 1951 May;11(5):388-92 - PubMed
    1. Lancet. 1977 Sep 17;2(8038):584-6 - PubMed
    1. Life Sci. 1978 Mar;22(11):979-83 - PubMed

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