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. 2023 Jan-Dec:29:10760296231173409.
doi: 10.1177/10760296231173409.

Factors Affecting Recanalization in Femoropopliteal Deep Vein Thrombosis

Mehmet Emir Erol  1 , Sertan Özyalçın  1 , Kudret Atakan Tekin  1 , Adem İlkay Diken  2 , Adnan Yalçınkaya  3 , Ertekin Utku Ünal  1
Affiliations

Factors Affecting Recanalization in Femoropopliteal Deep Vein Thrombosis

Mehmet Emir Erol et al. Clin Appl Thromb Hemost. 2023 Jan-Dec.

Abstract

Effects of warfarin and new-generation direct oral anticoagulants (DOACs) on thrombus resolution after the treatment of deep vein thrombosis (DVT) are still unknown. The study aimed to investigate the effects of warfarin and DOACs on thrombus resolution after DVT treatment. Methods: The study included 666 patients who were diagnosed with femoropopliteal DVT between January 2016 and January 2022 and had complete medical records without missing data. Patients with and without recanalization were added to groups 1 (n = 396) and 2 (n = 270), respectively. Ultrasonography/venous Doppler examinations of the patients during follow-up were performed by 3 radiologists. Recanalization was defined as the presence of complete flow in the femoral and popliteal veins and the absence of residual venous thrombus. Results: Among the included patients, recanalization was observed in 59.5% patients. The mean follow-up period was 23.6 ± 17.8 (range 1-72; median 17) months. There was no difference between the 2 groups in terms of the types of drugs used in the treatment (P = .208). Cox regression models were used to investigate the factors affecting recanalization. Analysis of the variables having significant differences between both groups revealed the low rate of recanalization in patients with coronary artery disease (odds ratio [OR], 2.3%; 95% confidence intervals [CI]: 1.6-3.4; P < .001) and diabetes mellitus (OR, 1.5; 95% CI: 1.1-1.9; P = .009). Conclusion: Thrombus resolution after femoropopliteal DVT is not affected by the drugs used in the treatment.

Keywords: deep venous thrombosis; direct oral anticoagulants; warfarin.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Cumulative risk in Cox regression analysis of 4 types of oral anticoagulants. Rivaroxaban and apixaban showed similar effects as warfarin (OR 0.7; 95% CI: 0.5-1.1; P = .082 and OR 0.8; 95% CI: 0.4-1.5; P = .468, respectively), while recanalization was relatively lower for dabigatran (OR 0.7; 95% CI: 0.5-0.9; P = .008). Abbreviations: CI, confidence interval; OR, odds ratio.
See this image and copyright information in PMC

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