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. 2023 Aug;30(8):2230-2239.
doi: 10.1111/ene.15859. Epub 2023 May 25.

NT-proBNP and changes in cognition and global brain structure: The Rotterdam Study

Tian Xiao  1 , Isabelle F van der Velpen  1   2 , Wiro J Niessen  1   2 , Martijn J Tilly  1 , Maryam Kavousi  1 , M Arfan Ikram  1 , M Kamran Ikram  1   3 , Meike W Vernooij  1   2
Affiliations

NT-proBNP and changes in cognition and global brain structure: The Rotterdam Study

Tian Xiao et al. Eur J Neurol. 2023 Aug.

Abstract

Objective: To investigate the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and changes in cognition and global brain structure.

Methods: In the Rotterdam Study, baseline NT-proBNP was assessed at baseline from 1997 to 2008. Between 1997 and 2016, participants without dementia or stroke at baseline (n = 9566) had repeated cognitive tests (every 3-6 years) for global cognitive function, executive cognitive function, fine manual dexterity, and memory. Magnetic resonance imaging of the brain was performed repeatedly at re-examination visits between 2005 and 2015 for 2607 participants to obtain brain volumes, focal brain lesions, and white matter microstructural integrity as measures of brain structure.

Results: Among 9566 participants (mean age 65.1 ± 9.8 years), 5444 (56.9%) were women, and repeated measures of cognition were performed during a median follow-up time of 5.5 (range 1.1-17.9) years, of whom 2607 participants completed at least one brain imaging scan. Higher levels of NT-proBNP were associated with a faster decline of scores in the global cognitive function (p value = 0.003) and the Word-Fluency test (p value = 0.003) but were not related to a steeper deterioration in brain volumes, global fractional anisotropy, and mean diffusivity, as indicators of white matter microstructural integrity, or focal brain lesions.

Conclusions: Higher baseline NT-proBNP levels were associated with a faster decline in cognition; however, no association with global brain structure was found.

Keywords: MRI; NT-proBNP, change; brain structure; cognition; repeated measurements.

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