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Case Reports
. 2023 Jul 18;67(7):e0027723.
doi: 10.1128/aac.00277-23. Epub 2023 May 11.

Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa

Morgan K Morelli  1 , Amy Kloosterboer  1 , Scott A Fulton  1   2 , Jennifer Furin  1   2 , Nicholas Newman  1 , Ahmed F Omar  1   2   3 , Laura J Rojas  2   4   5 , Steven H Marshall  4 , Mohamad Yasmin  4 , Robert A Bonomo  2   4   5
Affiliations
Case Reports

Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa

Morgan K Morelli et al. Antimicrob Agents Chemother. .

Abstract

Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer with hypopyon. Culture of corneal scrapings grew extensively drug-resistant Pseudomonas aeruginosa. Treatment involved a combination of systemic and topical antibiotics. Whole genome sequencing revealed the presence of blaVIM-80, blaGES-9, and other resistance determinants. This distinctive organism was linked to an over-the-counter artificial tears product.

Keywords: Pseudomonas aeruginosa; antibacterial agents; cefiderocol; corneal ulcer; imipenem; keratitis; lubricant eye drops; polymyxin B.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIG 1
FIG 1
Total hypopyon with amniotic membrane in place to facilitate healing of the total epithelial defect.
See this image and copyright information in PMC

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