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Comment
. 2023 Jun 5;155(6):e202313402.
doi: 10.1085/jgp.202313402. Epub 2023 May 11.

Phosphoinositide regulation of voltage-gated sodium channels

Ben Short
Comment

Phosphoinositide regulation of voltage-gated sodium channels

Ben Short. J Gen Physiol. .

Abstract

JGP study (Gada et al. 2023. J. Gen. Physiol. https://doi.org/10.1085/jgp.202213255) reveals that the membrane lipid PI(4,5)P2 alters the activity of NaV1.4 channels by modulating their gating behavior.

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Figures

None
Leigh Plant (left), Kirin Gada (right), and colleagues reveal that the phospholipid PI(4,5)P2 regulates the gating of the voltage-gated sodium channel NaV1.4. Compared to control conditions (black line, right), depleting plasma membrane PI(4,5)P2 (blue line) shifts the voltage-dependent activation of NaV1.4 by approximately −10 mV. PI(4,5)P2 depletion also alters the rate and extent of fast inactivation, as well as the channel’s recovery from fast inactivation. BL, blue light.
See this image and copyright information in PMC

Comment on

  • PI(4,5)P2 regulates the gating of NaV1.4 channels.
    Gada KD, Kamuene JM, Chandrashekar A, Kissell RC, Yauch AK, Plant LD. Gada KD, et al. J Gen Physiol. 2023 Jun 5;155(6):e202213255. doi: 10.1085/jgp.202213255. Epub 2023 Apr 12. J Gen Physiol. 2023. PMID: 37043561 Free PMC article.

References

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    1. Gada, K.D., and Logothetis D.E.. 2022. J. Biol. Chem. 10.1016/j.jbc.2022.102035 - DOI - PMC - PubMed
    1. Gada, K.D., et al. . 2023. J. Gen. Physiol. 10.1085/jgp.202213255 - DOI - PMC - PubMed
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    1. Mantegazza, M., et al. . 2021. Physiol. Rev. 10.1152/physrev.00025.2020 - DOI - PMC - PubMed

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