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Meta-Analysis
. 2023 Apr 24:29:1611055.
doi: 10.3389/pore.2023.1611055. eCollection 2023.

Prognostic role of pretreatment skeletal muscle index in gastric cancer patients: A meta-analysis

Xiaohong He  1   2 , Sicheng Zhou  2 , Hongjun Li  2 , Yue Gou  2 , Dan Jia  2
Affiliations
Meta-Analysis

Prognostic role of pretreatment skeletal muscle index in gastric cancer patients: A meta-analysis

Xiaohong He et al. Pathol Oncol Res. .

Abstract

Background: The association between pretreatment skeletal muscle index (SMI) and long-term survival of gastric cancer patients remains unclear up to now. The aim of this meta-analysis was to identify the prognostic value of pretreatment SMI in gastric cancer. Methods: The PubMed, EMBASE and Web of Science electronic databases were searched up to 5 June 2022 for relevant studies. The primary outcome was overall survival (OS) and the second outcomes were disease-free survival (DFS) and cancer-specific survival (CSS). The hazard ratios (HRs) and 95% confidence intervals (CIs) were combined to assess the relationship between pretreatment SMI and survival of gastric cancer patients. All statistical analyses were conducted by STATA 15.0 software. Results: A total of 31 retrospective studies involving 12,434 patients were enrolled in this meta-analysis. The pooled results demonstrated that lower pretreatment was significantly associated with poorer OS (HR = 1.53, p < 0.001). Besides, lower pretreatment SMI was also related with worse DFS (HR = 1.39, p < 0.001) and CSS (HR = 1.96, p < 0.001). Conclusion: Pretreatment SMI was significantly associated with prognosis of gastric cancer patients and lower SMI predicted worse survival. However, more prospective high-quality studies are still needed to verify our findings.

Keywords: gastric cancer; meta-analysis; pretreatment; prognosis; skeletal muscle index.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The flow diagram of this meta-analysis.
FIGURE 2
FIGURE 2
The association between pretreatment skeletal muscle index and overall survival in gastric cancer.
FIGURE 3
FIGURE 3
The association between pretreatment skeletal muscle index and disease free survival in gastric cancer.
FIGURE 4
FIGURE 4
Sensitivity analysis about the association between pretreatment skeletal muscle index and overall survival in gastric cancer.
FIGURE 5
FIGURE 5
Begg’s funnel plot.
FIGURE 6
FIGURE 6
Filled Begg’s funnel plot.
See this image and copyright information in PMC

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