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Case Reports
. 2023 Apr 15:32:100372.
doi: 10.1016/j.jctube.2023.100372. eCollection 2023 Aug.

Clinical features of human tuberculosis due to Mycobacterium orygis in Southern India

Lydia Jennifer Sumanth  1 , Christina Rachel Suresh  2 , Manigandan Venkatesan  3 , Abi Manesh  4 , Marcel A Behr  5 , Vivek Kapur  6 , Joy Sarojini Michael  7
Affiliations
Case Reports

Clinical features of human tuberculosis due to Mycobacterium orygis in Southern India

Lydia Jennifer Sumanth et al. J Clin Tuberc Other Mycobact Dis. .

Abstract

Mycobacterium orygis is a member of the Mycobacterium tuberculosis complex (MTBC) and causes tuberculosis in a variety of animals, including humans in South Asia. Here, we describe the clinical features associated with 8 human cases of whole genome sequence (WGS) confirmed M. orygis from a tertiary care hospital in South India during 2018-2019. The patient ages ranged from 9 to 51 years, with 5 females and 3 males included. All the patients had extrapulmonary disease with 2 having concomitant pulmonary involvement. Clinical improvement was documented after a full course of anti-tuberculosis therapy in 6 cases for whom follow-up was available. Taken together, the results show that M. orygis causes human tuberculosis in India, with a predominant extrapulmonary disease. Standardized molecular assays of this emerging member of the MTBC are needed to provide further information on the frequency of M. orygis infection in India and other countries where it is found in livestock and domestic wildlife.

Keywords: M. orygis; South India.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
(A) Sagittal T2-weighted Magnetic resonance imaging (MRI) spine without contrast of 9-year-old female (case 1) showing near complete destruction of L2 (Lumbar) vertebra with pre- and paravertebral collection with bilateral psoas collection. (B) Sagittal T2-weighted MRI spine with contrast of 47-year-old male (case 2) showing interval increase in the destruction of T6-T7 (Thoracic) vertebral bodies, increase in extent of prevertebral, paravertebral, epidural and anterior subligamentous extension. (C) Thoracic spine anteroposterior (AP) view of 24-year-old male (case 4) showing paravertebral abscess at the level of T10 vertebra requiring decompression and stabilization. (D) Case 4 thoracic spine AP view post-surgical correction. (E) Case 4 thoracic spine lateral view post-surgical correction. (F) Chest radiography AP view of 16-year-old female (Case 6) shows bilateral lung nodular consolidation. (G) Computed Tomography (CT) of thorax without contrast of 16-year-old female (Case 8) shows consolidation with cystic changes of entire right lower lobe with branching nodular opacities in superior basal segment of right lower lobe.
See this image and copyright information in PMC

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