Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 May;5(5):760-761.
doi: 10.1038/s42255-023-00792-0. Epub 2023 May 11.

Revisiting the role of serine metabolism in hepatic lipogenesis

Hong Yang  1 , Cheng Zhang  1 , Hasan Turkez  2 , Mathias Uhlen  1 , Jan Boren  3 , Adil Mardinoglu  4   5
Affiliations
Comment

Revisiting the role of serine metabolism in hepatic lipogenesis

Hong Yang et al. Nat Metab. 2023 May.
No abstract available

PubMed Disclaimer

Comment in

Comment on

References

    1. Zhang, Z. et al. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat. Metab. 3, 1608–1620 (2021). - DOI - PubMed - PMC
    1. Jin, E. S., Lee, M. H., Murphy, R. E. & Malloy, C. R. Pentose phosphate pathway activity parallels lipogenesis but not antioxidant processes in rat liver. Am. J. Physiol. Endocrinol. Metab. 314, E543–E551 (2018). - DOI - PubMed - PMC
    1. Bianchi, G. et al. Impaired insulin-mediated amino acid plasma disappearance in non-alcoholic fatty liver disease: a feature of insulin resistance. Dig. Liver Dis. 35, 722–727 (2003). - DOI - PubMed
    1. Mardinoglu, A. et al. Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. Nat. Commun. 5, 3083 (2014). - DOI - PubMed
    1. Zhou, Y. et al. Noninvasive detection of nonalcoholic steatohepatitis using clinical markers and circulating levels of lipids and metabolites. Clin. Gastroenterol. Hepatol. 14, 1463–1472 (2016). - DOI - PubMed

Publication types

LinkOut - more resources