Reply to: revisiting the role of serine metabolism in hepatic lipogenesis

Zhaoyue Zhang^{1

2}, Tara TeSlaa^{3

4}, Joshua D Rabinowitz^{5

6

7}

Affiliations

¹ Department of Chemistry, Princeton University, Princeton, NJ, USA.
² Laboratory of Molecular Genetics, The Rockefeller University, New York, NY, USA.
³ Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
⁴ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
⁵ Department of Chemistry, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.
⁶ Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.
⁷ Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA. joshr@princeton.edu.

Comment

Zhaoyue Zhang et al. Nat Metab. 2023 May.

. 2023 May;5(5):762-764.

doi: 10.1038/s42255-023-00793-z. Epub 2023 May 11.

Zhaoyue Zhang^{1

2}, Tara TeSlaa^{3

4}, Joshua D Rabinowitz^{5

6

7}

¹ Department of Chemistry, Princeton University, Princeton, NJ, USA.
² Laboratory of Molecular Genetics, The Rockefeller University, New York, NY, USA.
³ Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.
⁴ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
⁵ Department of Chemistry, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.
⁶ Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. joshr@princeton.edu.
⁷ Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA. joshr@princeton.edu.

No abstract available

Comment on

Serine catabolism generates liver NADPH and supports hepatic lipogenesis.
Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz GJ, Clasquin MF, Rabinowitz JD. Zhang Z, et al. Nat Metab. 2021 Dec;3(12):1608-1620. doi: 10.1038/s42255-021-00487-4. Epub 2021 Nov 29. Nat Metab. 2021. PMID: 34845393 Free PMC article.
Revisiting the role of serine metabolism in hepatic lipogenesis.
Yang H, Zhang C, Turkez H, Uhlen M, Boren J, Mardinoglu A. Yang H, et al. Nat Metab. 2023 May;5(5):760-761. doi: 10.1038/s42255-023-00792-0. Epub 2023 May 11. Nat Metab. 2023. PMID: 37169876 No abstract available.

1. Ducker, G. S. et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B cell lymphoma. Proc. Natl Acad. Sci. USA 114, 11404–11409 (2017). - DOI - PubMed - PMC
1. Ducker, G. S. & Rabinowitz, J. D. One-carbon metabolism in health and disease. Cell Metab. 25, 27–42 (2017). - DOI - PubMed
1. Jin, E. S., Lee, M. H., Murphy, R. E. & Malloy, C. R. Pentose phosphate pathway activity parallels lipogenesis but not antioxidant processes in rat liver. Am. J. Physiol. Endocrinol. Metab. 314, E543–E551 (2018). - DOI - PubMed - PMC
1. Wise, E. M. & Ball, E. G. Malic enzyme and lipogenesis. Proc. Natl Acad. Sci. USA 52, 1255–1263 (1964). - DOI - PubMed - PMC
1. Frenkel, R. Regulation and physiological functions of malic enzymes. Curr. Top. Cell Regul. 9, 157–181 (1975). - DOI - PubMed