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. 2023 Jun;38(6):699-711.
doi: 10.1007/s10654-023-01008-1. Epub 2023 May 12.

Cohort profile update: Tehran cardiometabolic genetic study

Maryam S Daneshpour  1 , Mahdi Akbarzadeh  2 , Hossein Lanjanian  2 , Bahar Sedaghati-Khayat  2   3 , Kamran Guity  2   4 , Sajedeh Masjoudi  2 , Asiyeh Sadat Zahedi  2 , Maryam Moazzam-Jazi  2 , Leila Najd Hassan Bonab  2 , Bita Shalbafan  5 , Sara Asgarian  2 , Goodarz Koli Farhood  2 , Niloofar Javanrooh  2 , Maryam Zarkesh  2 , Parisa Riahi  2 , Mohammad Reza Moghaddas  2 , Parvaneh Arbab Dehkordi  2 , Azar Delbarpour Ahmadi  2 , Firoozeh Hosseini  6 , Sara Jalali Farahani  7 , Farzad Hadaegh  8 , Parvin Mirmiran  6 , Fahimeh Ramezani Tehrani  9 , Arash Ghanbarian  8 , Mohammad Sadegh Fallah Mahboob Pasand  10 , Parisa Amiri  7 , Majid Valizadeh  11 , Farhad Hosseipanah  11 , Maryam Tohidi  8 , Asghar Ghasemi  12 , Azita Zadeh-Vakili  12 , Mohammad Piryaei  2 , Shahram Alamdari  13 , Davood Khalili  8 , Amirabbas Momenan  8 , Maryam Barzin  11 , Sirous Zeinali  10 , Mehdi Hedayati  2 , Fereidoun Azizi  14
Affiliations

Cohort profile update: Tehran cardiometabolic genetic study

Maryam S Daneshpour et al. Eur J Epidemiol. 2023 Jun.

Abstract

The Tehran cardiometabolic genetic study (TCGS) is a large population-based cohort study that conducts periodic follow-ups. TCGS has created a comprehensive database comprising 20,367 participants born between 1911 and 2015 selected from four main ongoing studies in a family-based longitudinal framework. The study's primary goal is to identify the potential targets for prevention and intervention for non-communicable diseases that may develop in mid-life and late life. TCGS cohort focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the TCGS cohort has augmented by encoding all health-related complications, including hospitalization outcomes and self-reports according to ICD11 coding, and verifying consanguineous marriage using genetic markers. This research provides an update on the rationale and design of the study, summarizes its findings, and outlines the objectives for precision medicine.

Keywords: Cardiometabolic biomarkers; Cohort study; Consanguineous marriage; Endocrine disease; Lifestyle; Nutrition; Precision medicine; Tehran cardiometabolic genetic study (TCGS).

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Description of projects which attended TCGS
See this image and copyright information in PMC

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