Bio-based polymers containing traditional medicinal fillers for wound healing applications - An evaluation of neoteric development and future perspectives

Abstract

In recent years, health-care providers have seen more patients with difficult-to-treat wounds and burns. The biopolymer-based wound dressing protects the wounded area while assisting in the recovery of dermal and epithelial tissues throughout the healing process. The overall number of patients with chronic lesions has been expanding due to developing society, over weight, and cardiovascular illness. For the treatment of chronic wounds, there is an increasing demand for the development of ideal wound dressing materials with excellent properties such as antibacterial activity, biocompatibility, free radical scavenging capacity, non-adherent property, hydrophilicity, and so on. Nevertheless, owing to the above mention properties, natural polymers are being used for several key functions of biomedicine like narcotic distribution systems, tissue manufacturing, bandages, and so on. Accordingly, the significance of these bio-based polymers interfered with healing functions that lead to informing and inspiring youth and scientist researchers worldwide to grab with these far-reaching areas of medicine and biology. The review highlights the physiochemical properties of natural polymers, the biological evaluation of various materials as wound dressings, their synthesis and mechanical properties, clinical status, challenges, and future perspectives.

Keywords: alginate; biopolymers; cellulose; chitosan; collagen; smart bandages; wound healing.