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. 2024;24(1):39-49.
doi: 10.2174/1871530323666230511140514.

Gut-Skin Axis: Unravelling the Link Between Gut Microbiome and Chronic Kidney Disease-Related Skin Lesions

Xiaomei Qiao  1 , Kaili Kong  1 , Ting Liu  2 , Yanyan Jia  2 , Jingai Fang  2 , Xiaodong Zhang  2
Affiliations

Gut-Skin Axis: Unravelling the Link Between Gut Microbiome and Chronic Kidney Disease-Related Skin Lesions

Xiaomei Qiao et al. Endocr Metab Immune Disord Drug Targets. 2024.

Abstract

It is well known that skin lesions are among the most common complications of chronic kidney disease (CKD), which significantly impact the patient's quality of life. Research has demonstrated that gut and skin lesions are closely interconnected and affect each other. This interaction is referred to as the "gut-skin axis" and the intestinal microbiota plays a critical role in this interaction. Changes in gut microbiota composition and function are associated with the development of skin diseases, which are part of the "gut-skin axis". Presently, preliminary results have been demonstrated in basic and clinical research on CKD skin lesions. With further research, the "gut-skin axis" theory can provide new ideas for treating CKD skin lesions and may become a potential treatment target.

Keywords: Chronic kidney disease; gut microbiome.; gut-skin axis; inflammation; skin lesions; uremic toxins.

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