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. 2023 Aug 1;42(8):695-697.
doi: 10.1097/INF.0000000000003948. Epub 2023 Apr 27.

High-throughput Sequencing to Identify Bacteremia in Children with Cancer

Son H McLaren  1 , Nischay Mishra  2 , Nobuko Hijiya  3 , James Ng  2 , Cheng Guo  2 , Susan Whittier  4 , Erica Mariani  5 , Laura Glaser  6 , Irene Frantzis  7 , Marc T Vindas  8 , Cheng-Shiun Leu  9 , Peter S Dayan  1
Affiliations

High-throughput Sequencing to Identify Bacteremia in Children with Cancer

Son H McLaren et al. Pediatr Infect Dis J. .

Abstract

Current methods to diagnose bacteremia are limited. In this pilot study of children with cancer presenting with fever, we determined the concordance between a novel high-throughput sequencing platform called BacCapSeq and blood culture. High-throughput sequencing had modest concordance with blood culture. Discordant organisms included those with both unlikely or potential clinical relevance.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

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