Beyond the unfolded protein response: Disclosing the role of XBP1s in Alzheimer's disease
- PMID: 37172589
- PMCID: PMC10362413
- DOI: 10.1016/j.ymthe.2023.04.015
Beyond the unfolded protein response: Disclosing the role of XBP1s in Alzheimer's disease
Conflict of interest statement
Declaration of interests The author declares no competing interests.
Comment on
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The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.Mol Ther. 2023 Jul 5;31(7):2240-2256. doi: 10.1016/j.ymthe.2023.03.028. Epub 2023 Apr 4. Mol Ther. 2023. PMID: 37016577 Free PMC article.
References
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- Duran-Aniotz C., Poblete N., Rivera-Krstulovic C., Ardiles Á.O., Díaz-Hung M.L., Tamburini G., Sabusap C.M.P., Gerakis Y., Cabral Miranda F., Diaz J., et al. The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis. Mol. Ther. 2023 doi: 10.1016/j.ymthe.2023.03.028. - DOI - PMC - PubMed
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- Cabral-Miranda F., Tamburini G., Martinez G., Ardiles A.O., Medinas D.B., Gerakis Y., Hung M.L.D., Vidal R., Fuentealba M., Miedema T., et al. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. EMBO J. 2022;41:e111952. doi: 10.15252/embj.2022111952. - DOI - PMC - PubMed
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