Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Jul 5;31(7):1868-1869.
doi: 10.1016/j.ymthe.2023.04.015. Epub 2023 May 11.

Beyond the unfolded protein response: Disclosing the role of XBP1s in Alzheimer's disease

Affiliations
Comment

Beyond the unfolded protein response: Disclosing the role of XBP1s in Alzheimer's disease

Elena Marcello. Mol Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The author declares no competing interests.

Comment on

References

    1. Duran-Aniotz C., Poblete N., Rivera-Krstulovic C., Ardiles Á.O., Díaz-Hung M.L., Tamburini G., Sabusap C.M.P., Gerakis Y., Cabral Miranda F., Diaz J., et al. The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis. Mol. Ther. 2023 doi: 10.1016/j.ymthe.2023.03.028. - DOI - PMC - PubMed
    1. Hetz C. Adapting the proteostasis capacity to sustain brain healthspan. Cell. 2021;184:1545–1560. doi: 10.1016/j.cell.2021.02.007. - DOI - PubMed
    1. Jiang D., Niwa M., Koong A.C. Targeting the IRE1α–XBP1 branch of the unfolded protein response in human diseases. Semin. Cancer Biol. 2015;33:48–56. doi: 10.1016/j.semcancer.2015.04.010. - DOI - PMC - PubMed
    1. Cabral-Miranda F., Tamburini G., Martinez G., Ardiles A.O., Medinas D.B., Gerakis Y., Hung M.L.D., Vidal R., Fuentealba M., Miedema T., et al. Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging. EMBO J. 2022;41:e111952. doi: 10.15252/embj.2022111952. - DOI - PMC - PubMed
    1. Duran-Aniotz C., Cornejo V.H., Espinoza S., Ardiles Á.O., Medinas D.B., Salazar C., Foley A., Gajardo I., Thielen P., Iwawaki T., et al. IRE1 signaling exacerbates Alzheimer’s disease pathogenesis. Acta Neuropathol. 2017;134:489–506. doi: 10.1007/s00401-017-1694-x. - DOI - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources