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Comment
. 2023 Jun;23(6):344.
doi: 10.1038/s41577-023-00889-3.

Copper boosts pro-inflammatory state of macrophages

Alexandra Flemming  1
Affiliations
Comment

Copper boosts pro-inflammatory state of macrophages

Alexandra Flemming. Nat Rev Immunol. 2023 Jun.

Abstract

Copper(ii) ions promote the metabolic and epigenetic remodelling of macrophages towards a pro-inflammatory state. A copper-binding metformin dimer showed promising results in mouse models of inflammation.

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Comment on

  • A druggable copper-signalling pathway that drives inflammation.
    Solier S, Müller S, Cañeque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Pantoș GD, Gandon V, Gaillet C, Wu TD, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, Péricat D, Näser E, Cougoule C, Meunier E, Bègue AL, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R. Solier S, et al. Nature. 2023 May;617(7960):386-394. doi: 10.1038/s41586-023-06017-4. Epub 2023 Apr 26. Nature. 2023. PMID: 37100912 Free PMC article.

References

    1. Solier S, et al. A druggable copper-signalling pathway that drives inflammation. Nature. 2023 doi: 10.1038/s41586-023-06017-4. - DOI - PMC - PubMed